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Cabyr Gene Detail
Summary
  • Symbol
    Cabyr
  • Name
    calcium binding tyrosine phosphorylation regulated
  • Synonyms
    1700016C01Rik, 4933421A18Rik, CBP86, FSP-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918382
    NCBI Gene: 71132
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:12874141-12888203 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 6.77 cM, cytoband A2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    455 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918382
 protein coding gene Chr18:12873379-12888317 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024162
 protein coding gene Chr18:9946807-9960451 (+)
A/J MGP_AJ_G0024124
 protein coding gene Chr18:9746928-9760705 (+)
AKR/J MGP_AKRJ_G0024091
 protein coding gene Chr18:10045547-10064043 (+)
BALB/cJ MGP_BALBcJ_G0024123
 protein coding gene Chr18:9700578-9714976 (+)
C3H/HeJ MGP_C3HHeJ_G0023890
 protein coding gene Chr18:9932936-9946709 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024568
 protein coding gene Chr18:10432681-10452738 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022008
 protein coding gene Chr18:9318383-9332251 (+)
CAST/EiJ MGP_CASTEiJ_G0023367
 protein coding gene Chr18:9810586-9824204 (+)
CBA/J MGP_CBAJ_G0023862
 protein coding gene Chr18:10583572-10599946 (+)
DBA/2J MGP_DBA2J_G0023991
 protein coding gene Chr18:9587297-9601828 (+)
FVB/NJ MGP_FVBNJ_G0023956
 protein coding gene Chr18:9462127-9476108 (+)
LP/J MGP_LPJ_G0024074
 protein coding gene Chr18:10023704-10038717 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023985
 protein coding gene Chr18:10733148-10749077 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024614
 protein coding gene Chr18:9818353-9832897 (+)
PWK/PhJ MGP_PWKPhJ_G0023113
 protein coding gene Chr18:9657894-9671670 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022922
 protein coding gene Chr18:10077294-10090614 (+)
WSB/EiJ MGP_WSBEiJ_G0023433
 protein coding gene Chr18:9811938-9825795 (+)



Homology
more
  • Human Ortholog
    CABYR, calcium binding tyrosine phosphorylation regulated
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CABYR, calcium binding tyrosine phosphorylation regulated
  • Synonyms
    CABYRa, CABYRc, CABYRc/d, CABYRe, CBP86, CT88, FSP-2, FSP2
  • Links
    NCBI Gene ID: 26256
    neXtProt AC: NX_O75952
    UniProt: O75952

  • Chr Location
    18q11.2; chr18:24138987-24161600 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cabyr mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout affects sperm flagellum morphology, resulting in reduced sperm motility. These mutant males are subfertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    9
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 71132 NCBI Gene Model | MGI Sequence Detail 14063 C57BL/6J ±  kb
    transcript NM_027687 RefSeq | MGI Sequence Detail 2125 Not Specified  
    polypeptide Q9D424 UniProt | EBI | MGI Sequence Detail 453 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000004939 calcium-binding tyrosine phosphorylation-regulated protein
      (term hierarchy)
    • InterPro Domains
      IPR047579 CABYR/SP17, dimerization domain
      IPR038848 Calcium-binding tyrosine phosphorylation-regulated protein
      IPR003117 cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain
    • GlyGen
      Q9D424 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1919109
    References
    more
    • Summaries
      All 29
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 8
      Phenotypes 2
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345053 Wang Y, et al., Coiled-coil domain-containing 38 is required for acrosome biogenesis and fibrous sheath assembly in mice. J Genet Genomics. 2023 Sep 13;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory