Scara5 MGI Mouse Gene Detail - MGI:1918395 - scavenger receptor class A, member 5

Symbol

Scara5
Name

scavenger receptor class A, member 5
Synonyms

4932433F15Rik, 4933425F03Rik

Feature Type

protein coding gene
IDs

MGI:1918395
NCBI Gene: 71145
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr14:65903852-66002275 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 34.35 cM, cytoband D1
Mapping Data

3 experiments

SNPs within 2kb

3089 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918395	protein coding gene	Chr14:65903852-66002275 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021483	protein coding gene	Chr14:60289312-60394745 (+)
A/J	MGP_AJ_G0021442	protein coding gene	Chr14:58887136-58986353 (+)
AKR/J	MGP_AKRJ_G0021418	protein coding gene	Chr14:60928594-61033687 (+)
BALB/cJ	MGP_BALBcJ_G0021448	protein coding gene	Chr14:58823521-58927479 (+)
C3H/HeJ	MGP_C3HHeJ_G0021225	protein coding gene	Chr14:60577648-60685220 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021887	protein coding gene	Chr14:63067728-63178966 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019427	protein coding gene	Chr14:56818987-56917110 (+)
CAST/EiJ	MGP_CASTEiJ_G0020742	protein coding gene	Chr14:57062982-57179678 (+)
CBA/J	MGP_CBAJ_G0021192	protein coding gene	Chr14:64979620-65091569 (+)
DBA/2J	MGP_DBA2J_G0021315	protein coding gene	Chr14:58534717-58635603 (+)
FVB/NJ	MGP_FVBNJ_G0021294	protein coding gene	Chr14:57935492-58041344 (+)
LP/J	MGP_LPJ_G0021390	protein coding gene	Chr14:61324418-61433623 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021323	protein coding gene	Chr14:64073637-64177395 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021910	protein coding gene	Chr14:60113429-60230495 (+)
PWK/PhJ	MGP_PWKPhJ_G0020486	protein coding gene	Chr14:55251584-55352553 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020319	protein coding gene	Chr14:56083251-56194594 (+)
WSB/EiJ	MGP_WSBEiJ_G0020795	protein coding gene	Chr14:60418889-60526949 (+)

Human Ortholog

SCARA5, scavenger receptor class A member 5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SCARA5, scavenger receptor class A member 5
Synonyms

NET33, Tesr
Links

HGNC:28701

NCBI Gene ID: 286133

neXtProt AC: NX_Q6ZMJ2

UniProt: Q6ZMJ2
Chr Location

8p21.1; chr8:27869883-27992673 (-) GRCh38

MGI Vertebrate Homology

Scara5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SCARA5
Gene Tree

Scara5

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

6
Targeted

1
Genomic Mutations

1 involving Scara5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

36 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous deletion of this gene results in decreased male fertility and lymphocytic infiltration of the stroma of various tissues, particularly in the lungs.

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All GO Annotations

9
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

762
Tissues

33
cDNA Data

48
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase scara5

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All Sequences

49
RefSeq

6
UniProt

2
CCDS

CCDS27214.1, CCDS49523.1

Ensembl

ENSMUSG00000022032 (Evidence)
NCBI Gene

71145

			Length	Strain/Species	Flank
genomic	71145	NCBI Gene Model \| MGI Sequence Detail	98424	C57BL/6J	± kb
transcript	NM_028903	RefSeq \| MGI Sequence Detail	3809	C57BL/6
polypeptide	Q8K299	UniProt \| EBI \| MGI Sequence Detail	491	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014492 scavenger receptor class A member 5

(term hierarchy)
PDB

7BZZ
InterPro Domains

IPR008160 Collagen triple helix repeat

IPR003543 Macrophage scavenger receptor, Class A-I/II

IPR034726 Scavenger receptor class A member 5

IPR001190 SRCR domain

IPR017448 SRCR-like domain

IPR036772 SRCR-like domain superfamily

IPR050686 SRCR-S1 Scavenger Receptor
GlyGen

Q8K299 7 sites, 2 N-linked glycans (2 sites)

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All nucleic 50

cDNA 48

Primer pair 1

Other 1

Microarray probesets 6

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MGI:1921628, MGI:2145782

Summaries

All 35

Developmental Gene Expression 4

Gene Ontology 3

Phenotypes 6
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Scara5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr126220	Chr14:65903843-65903865 (+)	2 bp
Tssr126221	Chr14:65903879-65903892 (+)	34 bp
Tssr4457	Chr14:65913341-65913345 (+)	9,491 bp
Tssr4458	Chr14:65920942-65920944 (+)	17,091 bp
Tssr126222	Chr14:65932277-65932282 (+)	28,428 bp
Tssr126223	Chr14:65968481-65968502 (+)	64,640 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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