Mier1 MGI Mouse Gene Detail - MGI:1918398 - MEIR1 treanscription regulator

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Mier1 Gene Detail

Symbol

Mier1
Name

MEIR1 treanscription regulator
Synonyms

4933425I22Rik, 5830411K19Rik, mKIAA1610

Feature Type

protein coding gene
IDs

MGI:1918398
NCBI Gene: 71148
Alliance

gene page
Transcription Start Sites

21 TSS

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Sequence Map

Chr4:102971587-103022951 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 47.36 cM, cytoband C6
Mapping Data

3 experiments

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SNPs within 2kb

1220 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_1918398	protein coding gene	Chr4:102971521-103022951 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028505	protein coding gene	Chr4:103526078-103579077 (+)
A/J	MGP_AJ_G0028468	protein coding gene	Chr4:99914144-99966086 (+)
AKR/J	MGP_AKRJ_G0028415	protein coding gene	Chr4:102339252-102392843 (+)
BALB/cJ	MGP_BALBcJ_G0028487	protein coding gene	Chr4:100111965-100164160 (+)
C3H/HeJ	MGP_C3HHeJ_G0028201	protein coding gene	Chr4:103121079-103172512 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028927	protein coding gene	Chr4:107436320-107489247 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026218	protein coding gene	Chr4:95265460-95317051 (+)
CAST/EiJ	MGP_CASTEiJ_G0027637	protein coding gene	Chr4:100881462-100934483 (+)
CBA/J	MGP_CBAJ_G0028170	protein coding gene	Chr4:110841892-110893668 (+)
DBA/2J	MGP_DBA2J_G0028318	protein coding gene	Chr4:99568740-99620178 (+)
FVB/NJ	MGP_FVBNJ_G0028285	protein coding gene	Chr4:98416769-98468081 (+)
LP/J	MGP_LPJ_G0028419	protein coding gene	Chr4:103807690-103859809 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028312	protein coding gene	Chr4:116283582-116337524 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028962	protein coding gene	Chr4:102554756-102606116 (+)
PWK/PhJ	MGP_PWKPhJ_G0027363	protein coding gene	Chr4:97781233-97833016 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027187	protein coding gene	Chr4:99977936-100028701 (+)
WSB/EiJ	MGP_WSBEiJ_G0027717	protein coding gene	Chr4:102721465-102772897 (+)

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Human Ortholog

MIER1, MIER1 transcriptional regulator

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MIER1, MIER1 transcriptional regulator
Synonyms

ER1, MI-ER1
Links

HGNC:29657

NCBI Gene ID: 57708

neXtProt AC: NX_Q8N108

UniProt: Q8N108
Chr Location

1p31.3; chr1:66924895-66988619 (+) GRCh38

MGI Vertebrate Homology

Mier1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MIER1
Gene Tree

Mier1

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
19 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

49
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

40
Radiation induced

1
Targeted

4
Genomic Mutations

4 involving Mier1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

45 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

18
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

710
Tissues

4
cDNA Data

20
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mier1

ZFIN mier1a, mier1b

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All Sequences

107
RefSeq

33
UniProt

5
CCDS

CCDS18408.1, CCDS38825.1, CCDS71432.1

Ensembl

ENSMUSG00000028522 (Evidence)
NCBI Gene

71148

Representative Sequences				Length	Strain/Species	Flank
	genomic	ENSMUSG00000028522	Ensembl Gene Model \| MGI Sequence Detail	51365	C57BL/6J	± kb
	transcript	ENSMUST00000097945	Ensembl \| MGI Sequence Detail	4698	Not Applicable
	polypeptide	ENSMUSP00000095558	Ensembl \| MGI Sequence Detail	556	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000010410 mesoderm induction early response protein 1

(term hierarchy)
InterPro Domains

IPR000949 ELM2 domain

IPR009057 Homeobox-like domain superfamily

IPR045787 Mesoderm induction early response protein 1/3, C-terminal

IPR040138 Mesoderm induction early response protein/metastasis-associated protein

IPR017884 SANT domain

IPR001005 SANT/Myb domain

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All nucleic 23

cDNA 22

Primer pair 1

Microarray probesets 5

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MGI:1923268

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Summaries

All 47

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 19
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Mier1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr38082	Chr4:102971582-102971591 (+)	0 bp
Tssr38083	Chr4:102971599-102971642 (+)	34 bp
Tssr38084	Chr4:102971659-102971672 (+)	79 bp
Tssr38085	Chr4:102971909-102971956 (+)	346 bp
Tssr38086	Chr4:102971973-102971989 (+)	394 bp
Tssr38087	Chr4:102972113-102972180 (+)	560 bp
Tssr38088	Chr4:102974416-102974448 (+)	2,845 bp
Tssr38089	Chr4:102976472-102976490 (+)	4,894 bp
Tssr38090	Chr4:102976568-102976600 (+)	4,997 bp
Tssr38091	Chr4:102976601-102976613 (+)	5,020 bp
Tssr38092	Chr4:102976631-102976644 (+)	5,051 bp
Tssr38093	Chr4:102976658-102976661 (+)	5,073 bp
Tssr38094	Chr4:102976664-102976683 (+)	5,087 bp
Tssr1248	Chr4:102977133-102977140 (+)	5,550 bp
Tssr38095	Chr4:102977467-102977492 (+)	5,893 bp
Tssr38096	Chr4:102980784-102980787 (+)	9,199 bp
Tssr38097	Chr4:102990726-102990731 (+)	19,142 bp
Tssr38098	Chr4:102992039-102992047 (+)	20,456 bp
Tssr38099	Chr4:103000249-103000268 (+)	28,672 bp
Tssr38100	Chr4:103008228-103008269 (+)	36,662 bp
Tssr38101	Chr4:103021838-103021842 (+)	50,253 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24