Nbas MGI Mouse Gene Detail - MGI:1918419 - neuroblastoma amplified sequence

Symbol

Nbas
Name

neuroblastoma amplified sequence
Synonyms

4933425L03Rik

Feature Type

protein coding gene
IDs

MGI:1918419
NCBI Gene: 71169
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr12:13319134-13633812 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 6.45 cM, cytoband A3
Mapping Data

3 experiments

SNPs within 2kb

8779 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918419	protein coding gene	Chr12:13319102-13687381 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019606	protein coding gene	Chr12:10526918-10858392 (+)
A/J	MGP_AJ_G0019572	protein coding gene	Chr12:10177497-10496034 (+)
AKR/J	MGP_AKRJ_G0019543	protein coding gene	Chr12:10785028-11119086 (+)
BALB/cJ	MGP_BALBcJ_G0019549	protein coding gene	Chr12:10382771-10700463 (+)
C3H/HeJ	MGP_C3HHeJ_G0019354	protein coding gene	Chr12:10619760-10950814 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019997	protein coding gene	Chr12:10898297-11251437 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017623	protein coding gene	Chr12:9852298-10147464 (+)
CAST/EiJ	MGP_CASTEiJ_G0018909	protein coding gene	Chr12:10505036-10843985 (+)
CBA/J	MGP_CBAJ_G0019325	protein coding gene	Chr12:11601581-11956576 (+)
DBA/2J	MGP_DBA2J_G0019438	protein coding gene	Chr12:10137415-10451127 (+)
FVB/NJ	MGP_FVBNJ_G0019429	protein coding gene	Chr12:10043217-10347407 (+)
LP/J	MGP_LPJ_G0019509	protein coding gene	Chr12:10648603-10974724 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019463	protein coding gene	Chr12:11385762-11725219 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020036	protein coding gene	Chr12:10416539-10743882 (+)
PWK/PhJ	MGP_PWKPhJ_G0018675	protein coding gene	Chr12:10206127-10535666 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018465	protein coding gene	Chr12:10543999-10882716 (+)
WSB/EiJ	MGP_WSBEiJ_G0018960	protein coding gene	Chr12:10517978-10836655 (+)

Human Ortholog

NBAS, NBAS subunit of NRZ tethering complex

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NBAS, NBAS subunit of NRZ tethering complex
Synonyms

ILFS2, NAG, SOPH
Links

HGNC:15625

NCBI Gene ID: 51594

neXtProt AC: NX_A2RRP1

UniProt: A2RRP1
Chr Location

2p24.3; chr2:14778909-15561340 (-) GRCh38

MGI Vertebrate Homology

Nbas stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NBAS
Gene Tree

Nbas

Diseases

1 with human NBAS associations

				Human Disease	Mouse Models
				infantile liver failure syndrome IDs infantile liver failure syndrome DOID:0080716 OMIM:PS615438 ORDO:370088

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

2
Gene trapped

7
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

101 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

9
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

749
Tissues

29
cDNA Data

78
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nbas

ZFIN nbas

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All Sequences

63
RefSeq

15
UniProt

8
CCDS

CCDS49031.1

Ensembl

ENSMUSG00000020576 (Evidence)
NCBI Gene

71169

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020576	Ensembl Gene Model \| MGI Sequence Detail	314679	C57BL/6J	± kb
transcript	ENSMUST00000042953	Ensembl \| MGI Sequence Detail	7234	Not Applicable
polypeptide	ENSMUSP00000036082	Ensembl \| MGI Sequence Detail	2356	Not Applicable

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UniProt

8 Sequences
InterPro Domains

IPR029145 Neuroblastoma-amplified sequence, N-terminal

IPR011044 Quinoprotein amine dehydrogenase, beta chain-like

IPR013244 Sec39 domain

IPR015943 WD40/YVTN repeat-like-containing domain superfamily
GlyGen

E9Q411 3 sites, 3 N-linked glycans (3 sites)

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All nucleic 80

cDNA 79

Primer pair 1

Microarray probesets 4

Summaries

All 34

Developmental Gene Expression 2

Gene Ontology 2

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Nbas:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr112823	Chr12:13319112-13319155 (+)	0 bp
Tssr112824	Chr12:13353251-13353263 (+)	34,123 bp
Tssr112825	Chr12:13353274-13353287 (+)	34,147 bp
Tssr112826	Chr12:13462770-13462786 (+)	143,644 bp
Tssr112827	Chr12:13488805-13488809 (+)	169,673 bp
Tssr112828	Chr12:13537113-13537140 (+)	217,993 bp
Tssr112829	Chr12:13551210-13551214 (+)	232,078 bp
Tssr3795	Chr12:13551225-13551230 (+)	232,094 bp
Tssr3796	Chr12:13551233-13551238 (+)	232,102 bp
Tssr112830	Chr12:13551241-13551250 (+)	232,112 bp
Tssr3797	Chr12:13586467-13586491 (+)	267,345 bp
Tssr112831	Chr12:13609176-13609183 (+)	290,046 bp
Tssr112832	Chr12:13614133-13614137 (+)	295,001 bp
Tssr3798	Chr12:13616128-13616153 (+)	297,007 bp
Tssr112833	Chr12:13616156-13616169 (+)	297,029 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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