Otud1 MGI Mouse Gene Detail - MGI:1918448

Symbol

Otud1
Name

OTU domain containing 1
Synonyms

4933428L19Rik

Feature Type

protein coding gene
IDs

MGI:1918448
NCBI Gene: 71198
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr2:19662563-19665394 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 13.78 cM
Mapping Data

1 experiment

SNPs within 2kb

81 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918448	protein coding gene	Chr2:19662542-19666090 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025384	protein coding gene	Chr2:17411051-17413882 (+)
A/J	MGP_AJ_G0025362	protein coding gene	Chr2:16689566-16692403 (+)
AKR/J	MGP_AKRJ_G0025330	protein coding gene	Chr2:17274828-17277665 (+)
BALB/cJ	MGP_BALBcJ_G0025357	protein coding gene	Chr2:16748804-16751635 (+)
C3H/HeJ	MGP_C3HHeJ_G0025117	protein coding gene	Chr2:17180233-17183064 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025800	protein coding gene	Chr2:17877191-17880022 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023215	protein coding gene	Chr2:16060168-16063003 (+)
CAST/EiJ	MGP_CASTEiJ_G0024581	protein coding gene	Chr2:17135624-17138470 (+)
CBA/J	MGP_CBAJ_G0025096	protein coding gene	Chr2:18639864-18642695 (+)
DBA/2J	MGP_DBA2J_G0025228	protein coding gene	Chr2:16630070-16632907 (+)
FVB/NJ	MGP_FVBNJ_G0025191	protein coding gene	Chr2:16434842-16437673 (+)
LP/J	MGP_LPJ_G0025315	protein coding gene	Chr2:17236477-17239308 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025222	protein coding gene	Chr2:18587294-18590126 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025858	protein coding gene	Chr2:17209105-17211936 (+)
PWK/PhJ	MGP_PWKPhJ_G0024330	protein coding gene	Chr2:16508904-16511748 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024130	protein coding gene	Chr2:17340912-17343743 (+)
WSB/EiJ	MGP_WSBEiJ_G0024651	protein coding gene	Chr2:17280997-17283833 (+)

Human Ortholog

OTUD1, OTU deubiquitinase 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

OTUD1, OTU deubiquitinase 1
Synonyms

DUBA7, OTDC1
Links

HGNC:27346

NCBI Gene ID: 220213

neXtProt AC: NX_Q5VV17

UniProt: Q5VV17
Chr Location

10p12.2; chr10:23439075-23442377 (+) GRCh38

MGI Vertebrate Homology

Otud1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: OTUD1
Gene Tree

Otud1

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

5
Transgenic

1
Genomic Mutations

1 involving Otud1
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele are more resistant to lethal HSV-1 and VSV infection, but are more susceptible to LPS stimulation.

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All GO Annotations

6
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

709
Tissues

1
cDNA Data

19
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase otud1

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All Sequences

31
RefSeq

3
UniProt

1
CCDS

CCDS50508.1

Ensembl

ENSMUSG00000043415 (Evidence)
NCBI Gene

71198

			Length	Strain/Species	Flank
genomic	ENSMUSG00000043415	Ensembl Gene Model \| MGI Sequence Detail	2832	C57BL/6J	± kb
transcript	ENSMUST00000052168	Ensembl \| MGI Sequence Detail	2832	Not Applicable
polypeptide	ENSMUSP00000100617	Ensembl \| MGI Sequence Detail	454	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000031031 OTU domain-containing protein 1

(term hierarchy)
EC

3.4.19.12
InterPro Domains

IPR003323 OTU domain

IPR050704 OTU domain-containing ubiquitin thioesterase

IPR047834 Ovarian tumor domain-containing protein 1, OTU domain

IPR038765 Papain-like cysteine peptidase superfamily

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All nucleic 21

Genomic 1

cDNA 19

Primer pair 1

Microarray probesets 3

Summaries

All 37

Developmental Gene Expression 3

Gene Ontology 4

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:343247 Zheng S, et al., OTUD1 ameliorates cerebral ischemic injury through inhibiting inflammation by disrupting K63-linked deubiquitination of RIP2. J Neuroinflammation. 2023 Nov 27;20(1):281

TSS for Otud1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr16419	Chr2:19662531-19662595 (+)	0 bp
Tssr16420	Chr2:19662624-19662635 (+)	67 bp
Tssr16421	Chr2:19662866-19662883 (+)	312 bp
Tssr16422	Chr2:19664856-19664890 (+)	2,310 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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