Slc29a3 MGI Mouse Gene Detail - MGI:1918529 - solute carrier family 29 (nucleoside transporters), member 3

Symbol

Slc29a3
Name

solute carrier family 29 (nucleoside transporters), member 3
Synonyms

4933435C21Rik, Ent3

Feature Type

protein coding gene
IDs

MGI:1918529
NCBI Gene: 71279
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr10:60547851-60588573 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 31.38 cM, cytoband B4
Mapping Data

3 experiments

SNPs within 2kb

1205 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918529	protein coding gene	Chr10:60547851-60588624 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017271	protein coding gene	Chr10:59970515-60015452 (-)
A/J	MGP_AJ_G0017249	protein coding gene	Chr10:58204378-58243535 (-)
AKR/J	MGP_AKRJ_G0017209	protein coding gene	Chr10:59728357-59766699 (-)
BALB/cJ	MGP_BALBcJ_G0017209	protein coding gene	Chr10:58278607-58324145 (-)
C3H/HeJ	MGP_C3HHeJ_G0017032	protein coding gene	Chr10:59628372-59668209 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017667	protein coding gene	Chr10:62115670-62154437 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015358	protein coding gene	Chr10:55185676-55225412 (-)
CAST/EiJ	MGP_CASTEiJ_G0016603	protein coding gene	Chr10:59599482-59641431 (-)
CBA/J	MGP_CBAJ_G0017004	protein coding gene	Chr10:64379035-64442468 (-)
DBA/2J	MGP_DBA2J_G0017109	protein coding gene	Chr10:57492171-57533849 (-)
FVB/NJ	MGP_FVBNJ_G0017103	protein coding gene	Chr10:56739423-56779920 (-)
LP/J	MGP_LPJ_G0017184	protein coding gene	Chr10:60385399-60427599 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017131	protein coding gene	Chr10:66804436-66849404 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017705	protein coding gene	Chr10:59524601-59565403 (-)
PWK/PhJ	MGP_PWKPhJ_G0016386	protein coding gene	Chr10:57310861-57355057 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016169	protein coding gene	Chr10:58857361-58902315 (-)
WSB/EiJ	MGP_WSBEiJ_G0016667	protein coding gene	Chr10:59449683-59491954 (-)

Human Ortholog

SLC29A3, solute carrier family 29 member 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC29A3, solute carrier family 29 member 3
Synonyms

ENT3, HCLAP, HJCD, PHID
Links

HGNC:23096

NCBI Gene ID: 55315

neXtProt AC: NX_Q9BZD2

UniProt: Q9BZD2
Chr Location

10q22.1; chr10:71319259-71381423 (+) GRCh38

MGI Vertebrate Homology

Slc29a3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC29A3
Protein SuperFamily

ENT
Gene Tree

Slc29a3

Diseases

1 with human SLC29A3 associations

				Human Disease	Mouse Models
				histiocytosis-lymphadenopathy plus syndrome IDs histiocytosis-lymphadenopathy plus syndrome DOID:0111278 NCI:C36075 OMIM:602782

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

67 phenotypes from 3 alleles in 3 genetic backgrounds
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

1
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Slc29a3
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit lymphadenopathy, splenomegaly, histiocytic sarcoma, and premature death associated with extramedullary hematopoiesis, increased macrophage proliferation and apoptosis and abnormal lysosome function.

less

All GO Annotations

65
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

707
Tissues

1
cDNA Data

43
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc29a3

less

All Sequences

53
RefSeq

8
UniProt

3
CCDS

CCDS48571.1

Ensembl

ENSMUSG00000020100 (Evidence)
NCBI Gene

71279

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020100	Ensembl Gene Model \| MGI Sequence Detail	40723	C57BL/6J	± kb
transcript	ENSMUST00000117513	Ensembl \| MGI Sequence Detail	5240	Not Applicable
polypeptide	ENSMUSP00000112685	Ensembl \| MGI Sequence Detail	475	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000015056 equilibrative nucleoside transporter 3

(term hierarchy)
InterPro Domains

IPR002259 Equilibrative nucleoside transporter
GlyGen

Q99P65 1 site

less

All nucleic 45

cDNA 44

Primer pair 1

Microarray probesets 4

less

MGI:3035493

Summaries

All 53

Developmental Gene Expression 2

Gene Ontology 8

Phenotypes 20
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:353041 Lu YS, et al., Equilibrative nucleoside transporter 3 supports microglial functions and protects against the progression of Huntington's disease in the mouse model. Brain Behav Immun. 2024 Aug;120:413-429

TSS for Slc29a3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr97733	Chr10:60588552-60588599 (-)	-3 bp
Tssr97732	Chr10:60580486-60580502 (-)	8,079 bp
Tssr97731	Chr10:60573973-60573977 (-)	14,598 bp
Tssr97730	Chr10:60560114-60560136 (-)	28,448 bp
Tssr97729	Chr10:60552067-60552089 (-)	36,495 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24