About   Help   FAQ
Arhgap26 Gene Detail
Summary
  • Symbol
    Arhgap26
  • Name
    Rho GTPase activating protein 26
  • Synonyms
    1810044B20Rik, 2610010G17Rik, 4933432P15Rik, mKIAA0621
Location &
Maps
more
  • Sequence Map
    Chr18:38734531-39509338 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 20.51 cM, cytoband B3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    21791 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918552
 protein coding gene Chr18:38734531-39509338 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024366
 protein coding gene Chr18:37076968-37911035 (+)
A/J MGP_AJ_G0024333
 protein coding gene Chr18:35790025-36582374 (+)
AKR/J MGP_AKRJ_G0024302
 protein coding gene Chr18:36759078-37575964 (+)
BALB/cJ MGP_BALBcJ_G0024333
 protein coding gene Chr18:35854642-36643061 (+)
C3H/HeJ MGP_C3HHeJ_G0024099
 protein coding gene Chr18:36841696-37654046 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024775
 protein coding gene Chr18:38395870-39219159 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022214
 protein coding gene Chr18:35792464-36580192 (+)
CAST/EiJ MGP_CASTEiJ_G0023574
 protein coding gene Chr18:36797854-37619239 (+)
CBA/J MGP_CBAJ_G0024069
 protein coding gene Chr18:39532404-40409524 (+)
DBA/2J MGP_DBA2J_G0024199
 protein coding gene Chr18:35382739-36167090 (+)
FVB/NJ MGP_FVBNJ_G0024165
 protein coding gene Chr18:35099350-35897811 (+)
LP/J MGP_LPJ_G0024283
 protein coding gene Chr18:37122320-37949668 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024196
 protein coding gene Chr18:40758563-41586868 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024824
 protein coding gene Chr18:36642724-37463499 (+)
PWK/PhJ MGP_PWKPhJ_G0023318
 protein coding gene Chr18:35613277-36411672 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023123
 protein coding gene Chr18:36853068-37702018 (+)
WSB/EiJ MGP_WSBEiJ_G0023637
 protein coding gene Chr18:36540029-37349463 (+)



Homology
more
  • Human Ortholog
    ARHGAP26, Rho GTPase activating protein 26
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARHGAP26, Rho GTPase activating protein 26
  • Synonyms
    GRAF, GRAF1, OPHN1L, OPHN1L1
  • Links
    NCBI Gene ID: 23092
    neXtProt AC: NX_Q9UNA1
    UniProt: Q9UNA1

  • Chr Location
    5q31.3; chr5:142770377-143229011 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human ARHGAP26 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a hypomorphic allele display reduced myofiber size, impaired myoblast fusion and abnormal muscle regeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    24
  • Tissues
    5
  • cDNA Data
    39
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 71302 NCBI Gene Model | MGI Sequence Detail 774808 C57BL/6J ±  kb
    transcript NM_175164 RefSeq | MGI Sequence Detail 7899 C57BL/6  
    polypeptide Q6ZQ82 UniProt | EBI | MGI Sequence Detail 814 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      cDNA 41

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1917050, MGI:1917571, MGI:2147280
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 1
      Gene Ontology 8
      Phenotypes 14
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:359111 Bai X, et al., GRAF1 deficiency leads to defective brown adipose tissue differentiation and thermogenic response. Sci Rep. 2024 Nov 20;14(1):28692
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory