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Fsip1 Gene Detail
Summary
  • Symbol
    Fsip1
  • Name
    fibrous sheath-interacting protein 1
  • Synonyms
    1700012M13Rik, 4933432K11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918563
    NCBI Gene: 71313
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:117960905-118087447 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 59.38 cM, cytoband E5
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3566 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918563
 protein coding gene Chr2:117960742-118087468 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026312
 protein coding gene Chr2:120882076-120935677 (-)
A/J MGP_AJ_G0026273
 protein coding gene Chr2:115970869-116024603 (-)
AKR/J MGP_AKRJ_G0026252
 protein coding gene Chr2:119231130-119284714 (-)
BALB/cJ MGP_BALBcJ_G0026286
 protein coding gene Chr2:116228208-116281059 (-)
C3H/HeJ MGP_C3HHeJ_G0026032
 protein coding gene Chr2:119680467-119734063 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026733
 protein coding gene Chr2:124869591-124927213 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024113
 protein coding gene Chr2:111020621-111071928 (-)
CAST/EiJ MGP_CASTEiJ_G0025494
 protein coding gene Chr2:119984617-120039686 (-)
CBA/J MGP_CBAJ_G0026008
 protein coding gene Chr2:129284258-129348927 (-)
DBA/2J MGP_DBA2J_G0026147
 protein coding gene Chr2:115394329-115447112 (-)
FVB/NJ MGP_FVBNJ_G0026109
 protein coding gene Chr2:114221041-114276008 (-)
LP/J MGP_LPJ_G0026248
 protein coding gene Chr2:121202977-121254827 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026128
 protein coding gene Chr2:133664582-133724355 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026788
 protein coding gene Chr2:119339191-119395955 (-)
PWK/PhJ MGP_PWKPhJ_G0025230
 protein coding gene Chr2:114946248-114996201 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025029
 protein coding gene Chr2:118510160-118565484 (-)
WSB/EiJ MGP_WSBEiJ_G0025563
 protein coding gene Chr2:120157823-120217016 (-)



Homology
more
  • Human Ortholog
    FSIP1, fibrous sheath interacting protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FSIP1, fibrous sheath interacting protein 1
  • Synonyms
    HSD10
  • Links
    NCBI Gene ID: 161835
    neXtProt AC: NX_Q8NA03
    UniProt: Q8NA03

  • Chr Location
    15q14; chr15:39588357-39782841 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null males show partial globozoospermia, impaired spermiogenesis, abnormal sperm morphology, including misshapen head, flagella assembly failure, and disrupted acrosome vesicle, reduced sperm numbers and decreased sperm motility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027344 Ensembl Gene Model | MGI Sequence Detail 126543 C57BL/6J ±  kb
    transcript ENSMUST00000231133 Ensembl | MGI Sequence Detail 2076 Not Applicable  
    polypeptide ENSMUSP00000155242 Ensembl | MGI Sequence Detail 593 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 6
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1922728
    References
    more
    • Summaries
      All 28
      Gene Ontology 2
      Phenotypes 8
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory