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Alpk1 Gene Detail
Summary
  • Symbol
    Alpk1
  • Name
    alpha-kinase 1
  • Synonyms
    8430410J10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918731
    NCBI Gene: 71481
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:127463959-127574176 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 56.54 cM, cytoband H1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3331 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918731
 protein coding gene Chr3:127460367-127574195 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027864
 protein coding gene Chr3:130178866-130289717 (-)
A/J MGP_AJ_G0027822
 protein coding gene Chr3:125720306-125821463 (-)
AKR/J MGP_AKRJ_G0027787
 protein coding gene Chr3:128969352-129079578 (-)
BALB/cJ MGP_BALBcJ_G0027835
 protein coding gene Chr3:125581621-125685607 (-)
C3H/HeJ MGP_C3HHeJ_G0027564
 protein coding gene Chr3:129348452-129452708 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028279
 protein coding gene Chr3:134875645-134988341 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025617
 protein coding gene Chr3:120965939-121070224 (-)
CAST/EiJ MGP_CASTEiJ_G0027021
 protein coding gene Chr3:128914334-129025434 (-)
CBA/J MGP_CBAJ_G0027540
 protein coding gene Chr3:139434890-139554820 (-)
DBA/2J MGP_DBA2J_G0027681
 protein coding gene Chr3:124936351-125041470 (-)
FVB/NJ MGP_FVBNJ_G0027648
 protein coding gene Chr3:122505961-122626871 (-)
LP/J MGP_LPJ_G0027790
 protein coding gene Chr3:131726492-131837017 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027679
 protein coding gene Chr3:147354097-147485982 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028336
 protein coding gene Chr3:128605385-128720632 (-)
PWK/PhJ MGP_PWKPhJ_G0026745
 protein coding gene Chr3:124670990-124773009 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026570
 protein coding gene Chr3:126690614-126802296 (-)
WSB/EiJ MGP_WSBEiJ_G0027100
 protein coding gene Chr3:129330411-129440525 (-)



Homology
more
  • Human Ortholog
    ALPK1, alpha kinase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ALPK1, alpha kinase 1
  • Synonyms
    8430410J10Rik, LAK, ROSAH
  • Links
    NCBI Gene ID: 80216
    neXtProt AC: NX_Q96QP1
    UniProt: Q96QP1

  • Chr Location
    4q25; chr4:112285509-112442621 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from multigenic genotypes
    12 phenotype references
Homozygosity for the p.T237M mutation leads to increased levels of certain chemokines.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    49
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028028 Ensembl Gene Model | MGI Sequence Detail 110218 C57BL/6J ±  kb
transcript ENSMUST00000198955 Ensembl | MGI Sequence Detail 4498 Not Applicable  
polypeptide ENSMUSP00000143223 Ensembl | MGI Sequence Detail 1231 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 6
    cDNA 6

    Microarray probesets 5
References
more
  • Summaries
    All 45
    Diseases 1
    Gene Ontology 10
    Phenotypes 12
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory