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Mcm9 Gene Detail
Summary
  • Symbol
    Mcm9
  • Name
    minichromosome maintenance 9 homologous recombination repair factor
  • Synonyms
    9030408O17Rik, Mcmdc1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918817
    NCBI Gene: 71567
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:53412411-53506535 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 27.21 cM, cytoband B3
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2495 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918817
 protein coding gene Chr10:53412411-53507251 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017230
 protein coding gene Chr10:52731923-52826007 (-)
A/J MGP_AJ_G0017206
 protein coding gene Chr10:51169562-51260850 (-)
AKR/J MGP_AKRJ_G0017166
 protein coding gene Chr10:52174675-52266900 (-)
BALB/cJ MGP_BALBcJ_G0017167
 protein coding gene Chr10:51309654-51401239 (-)
C3H/HeJ MGP_C3HHeJ_G0016990
 protein coding gene Chr10:52435120-52526295 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017626
 protein coding gene Chr10:54373892-54475518 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015320
 protein coding gene Chr10:48341152-48430300 (-)
CAST/EiJ MGP_CASTEiJ_G0016563
 protein coding gene Chr10:52534706-52630548 (-)
CBA/J MGP_CBAJ_G0016962
 protein coding gene Chr10:56701897-56791537 (-)
DBA/2J MGP_DBA2J_G0017067
 protein coding gene Chr10:50606510-50698226 (-)
FVB/NJ MGP_FVBNJ_G0017062
 protein coding gene Chr10:49904057-49995252 (-)
LP/J MGP_LPJ_G0017142
 protein coding gene Chr10:52798276-52892228 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017091
 protein coding gene Chr10:58644488-58741508 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017663
 protein coding gene Chr10:52095578-52189846 (-)
PWK/PhJ MGP_PWKPhJ_G0016344
 protein coding gene Chr10:50459747-50549583 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016130
 protein coding gene Chr10:51724224-51816659 (-)
WSB/EiJ MGP_WSBEiJ_G0016628
 protein coding gene Chr10:52337943-52430625 (-)



Homology
more
  • Human Ortholog
    MCM9, minichromosome maintenance 9 homologous recombination repair factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MCM9, minichromosome maintenance 9 homologous recombination repair factor
  • Synonyms
    C6orf61, dJ329L24.1, dJ329L24.3, MCMDC1, ODG4
  • Links
    NCBI Gene ID: 254394
    neXtProt AC: NX_Q9NXL9
    UniProt: Q9NXL9

  • Chr Location
    6q22.31; chr6:118813442-118935162 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Mcm9 mouse models; 1 with human MCM9 associations

Human Disease Mouse Models
      
IDs
 View 3 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 3 alleles in 2 genetic backgrounds
    1 images
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for gene trap alleles display germ cell loss with reduced fertility or infertility and increased tumor incidence, particulary of hepatocellular carcinomas.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    52
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    781
  • Tissues
    23
  • cDNA Data
    15
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000058298 Ensembl Gene Model | MGI Sequence Detail 94125 C57BL/6J ±  kb
    transcript ENSMUST00000075540 Ensembl | MGI Sequence Detail 4868 Not Applicable  
    polypeptide ENSMUSP00000074978 Ensembl | MGI Sequence Detail 1290 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 16
      Primer pair 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2682936, MGI:2685081
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 13
      Phenotypes 20
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:281866 Lutzmann M, et al., MCM8- and MCM9 Deficiencies Cause Lifelong Increased Hematopoietic DNA Damage Driving p53-Dependent Myeloid Tumors. Cell Rep. 2019 Sep 10;28(11):2851-2865.e4
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory