Tmt1b MGI Mouse Gene Detail - MGI:1918914 - thiol methyltransferase 1B

Symbol

Tmt1b
Name

thiol methyltransferase 1B
Synonyms

0610006F02Rik, Mettl7b

Feature Type

protein coding gene
IDs

MGI:1918914
NCBI Gene: 71664
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr10:128794146-128796857 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 77.20 cM, cytoband D3
Mapping Data

3 experiments

SNPs within 2kb

142 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918914	protein coding gene	Chr10:128794143-128796857 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017892	protein coding gene	Chr10:132760282-132762993 (-)
A/J	MGP_AJ_G0017867	protein coding gene	Chr10:127416124-127418827 (-)
AKR/J	MGP_AKRJ_G0017830	protein coding gene	Chr10:131135479-131138186 (-)
BALB/cJ	MGP_BALBcJ_G0017831	protein coding gene	Chr10:127775388-127778091 (-)
C3H/HeJ	MGP_C3HHeJ_G0017654	protein coding gene	Chr10:131307360-131310063 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018286	protein coding gene	Chr10:137232648-137235359 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015964	protein coding gene	Chr10:121322205-121324897 (-)
CAST/EiJ	MGP_CASTEiJ_G0017215	protein coding gene	Chr10:132040020-132042713 (-)
CBA/J	MGP_CBAJ_G0017624	protein coding gene	Chr10:142831266-142833965 (-)
DBA/2J	MGP_DBA2J_G0017730	protein coding gene	Chr10:126472405-126475120 (-)
FVB/NJ	MGP_FVBNJ_G0017725	protein coding gene	Chr10:125394555-125397262 (-)
LP/J	MGP_LPJ_G0017804	protein coding gene	Chr10:133337014-133341005 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017753	protein coding gene	Chr10:145384620-145387346 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018326	protein coding gene	Chr10:131240638-131243341 (-)
PWK/PhJ	MGP_PWKPhJ_G0017000	protein coding gene	Chr10:126741987-126745378 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016789	protein coding gene	Chr10:130357520-130360309 (-)
WSB/EiJ	MGP_WSBEiJ_G0017274	protein coding gene	Chr10:131474161-131476945 (-)

Human Ortholog

TMT1B, thiol methyltransferase 1B

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMT1B, thiol methyltransferase 1B
Synonyms

ALDI, METTL7B
Links

HGNC:28276

NCBI Gene ID: 196410

neXtProt AC: NX_Q6UX53

UniProt: Q6UX53
Chr Location

12q13.2; chr12:55681736-55684611 (+) GRCh38

MGI Vertebrate Homology

Tmt1b stringent orthology
1 human;1 mouse;1 rat;3 zebrafish
HCOP

vertebrate homology predictions: TMT1B
Gene Tree

Tmt1b

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

2
Targeted

3
Incidental Mutations

APF
Find Mice (IMSR)

8 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

9
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

876
Tissues

162
cDNA Data

148
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

28
RefSeq

2
UniProt

1
CCDS

CCDS24301.1

Ensembl

ENSMUSG00000025347 (Evidence)
NCBI Gene

71664

			Length	Strain/Species	Flank
genomic	71664	NCBI Gene Model \| MGI Sequence Detail	2712	C57BL/6J	± kb
transcript	NM_027853	RefSeq \| MGI Sequence Detail	1227	C57BL/6
polypeptide	Q9DD20	UniProt \| EBI \| MGI Sequence Detail	244	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000010353 thiol S-methyltransferase TMT1B

(term hierarchy)
EC

2.1.1.9
InterPro Domains

IPR013216 Methyltransferase type 11

IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily

IPR052356 Thiol S-methyltransferase
GlyGen

Q9DD20 1 site, 1 O-linked glycan (1 site)

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All nucleic 148

cDNA 148

Microarray probesets 2

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MGI:2143555, MGI:7461483

Summaries

All 35

Developmental Gene Expression 3

Gene Ontology 5

Phenotypes 8
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tmt1b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr3402	Chr10:128796881-128796882 (-)	-25 bp
Tssr99984	Chr10:128796834-128796851 (-)	14 bp
Tssr99983	Chr10:128796817-128796828 (-)	34 bp
Tssr99982	Chr10:128796694-128796722 (-)	149 bp
Tssr99981	Chr10:128796540-128796564 (-)	305 bp
Tssr99980	Chr10:128796481-128796508 (-)	362 bp
Tssr99979	Chr10:128794814-128794823 (-)	2,038 bp
Tssr99978	Chr10:128794674-128794685 (-)	2,177 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24