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Tmem25 Gene Detail
Summary
  • Symbol
    Tmem25
  • Name
    transmembrane protein 25
  • Synonyms
    0610039J01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918937
    NCBI Gene: 71687
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:44705066-44710604 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 24.84 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    151 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918937
 protein coding gene Chr9:44705066-44710821 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034719
 protein coding gene Chr9:43323272-43328813 (-)
A/J MGP_AJ_G0034700
 protein coding gene Chr9:42104619-42110158 (-)
AKR/J MGP_AKRJ_G0034627
 protein coding gene Chr9:42978777-42984316 (-)
BALB/cJ MGP_BALBcJ_G0034691
 protein coding gene Chr9:41844973-41850512 (-)
C3H/HeJ MGP_C3HHeJ_G0034402
 protein coding gene Chr9:43428870-43434409 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035212
 protein coding gene Chr9:44601572-44607103 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032127
 protein coding gene Chr9:41665751-41671056 (-)
CAST/EiJ MGP_CASTEiJ_G0033724
 protein coding gene Chr9:43290098-43295619 (-)
CBA/J MGP_CBAJ_G0034374
 protein coding gene Chr9:46231592-46237131 (-)
DBA/2J MGP_DBA2J_G0034533
 protein coding gene Chr9:42002291-42007830 (-)
FVB/NJ MGP_FVBNJ_G0034474
 protein coding gene Chr9:41263541-41269080 (-)
LP/J MGP_LPJ_G0034614
 protein coding gene Chr9:43623265-43628806 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034518
 protein coding gene Chr9:48074172-48079711 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035233
 protein coding gene Chr9:42900947-42906478 (-)
PWK/PhJ MGP_PWKPhJ_G0033429
 protein coding gene Chr9:41888072-41893613 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033265
 protein coding gene Chr9:43196357-43201934 (-)
WSB/EiJ MGP_WSBEiJ_G0033837
 protein coding gene Chr9:42922503-42928034 (-)



Homology
more
  • Human Ortholog
    TMEM25, transmembrane protein 25
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM25, transmembrane protein 25
  • Links
    NCBI Gene ID: 84866
    neXtProt AC: NX_Q86YD3
    UniProt: Q86YD3

  • Chr Location
    11q23.3; chr11:118531041-118547286 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype reference
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    3
  • cDNA Data
    19
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000002032 Ensembl Gene Model | MGI Sequence Detail 5539 C57BL/6J ±  kb
transcript ENSMUST00000002100 Ensembl | MGI Sequence Detail 2448 Not Applicable  
polypeptide ENSMUSP00000002100 Ensembl | MGI Sequence Detail 365 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 20
    Genomic 1
    cDNA 19

    Microarray probesets 3
Other
Accession IDs
less
MGI:2143046
References
more
  • Summaries
    All 26
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 1
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:335171 Bi J, et al., TMEM25 inhibits monomeric EGFR-mediated STAT3 activation in basal state to suppress triple-negative breast cancer progression. Nat Commun. 2023 Apr 24;14(1):2342
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory