Colec11 MGI Mouse Gene Detail - MGI:1918943 - collectin sub-family member 11

Symbol

Colec11
Name

collectin sub-family member 11
Synonyms

1010001H16Rik

Feature Type

protein coding gene
IDs

MGI:1918943
NCBI Gene: 71693
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr12:28644172-28673376 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 10.98 cM, cytoband B1
Mapping Data

2 experiments

SNPs within 2kb

1109 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918943	protein coding gene	Chr12:28644171-28673458 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019642	protein coding gene	Chr12:26425182-26456006 (-)
A/J	MGP_AJ_G0019609	protein coding gene	Chr12:25717499-25746570 (-)
AKR/J	MGP_AKRJ_G0019580	protein coding gene	Chr12:26573991-26604467 (-)
BALB/cJ	MGP_BALBcJ_G0019586	protein coding gene	Chr12:25966062-25997390 (-)
C3H/HeJ	MGP_C3HHeJ_G0019390	protein coding gene	Chr12:26435670-26466082 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020033	protein coding gene	Chr12:27275252-27311914 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017658	protein coding gene	Chr12:25073809-25103058 (-)
CAST/EiJ	MGP_CASTEiJ_G0018945	protein coding gene	Chr12:21402111-21431187 (-)
CBA/J	MGP_CBAJ_G0019361	protein coding gene	Chr12:28239880-28273437 (-)
DBA/2J	MGP_DBA2J_G0019475	protein coding gene	Chr12:25568641-25598058 (-)
FVB/NJ	MGP_FVBNJ_G0019466	protein coding gene	Chr12:25370289-25399992 (-)
LP/J	MGP_LPJ_G0019545	protein coding gene	Chr12:26514819-26545566 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019501	protein coding gene	Chr12:27866676-27901546 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020073	protein coding gene	Chr12:26091692-26122646 (-)
PWK/PhJ	MGP_PWKPhJ_G0018712	protein coding gene	Chr12:20275123-20305051 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018500	protein coding gene	Chr12:20668419-20703044 (-)
WSB/EiJ	MGP_WSBEiJ_G0018996	protein coding gene	Chr12:26293267-26325949 (-)

Human Ortholog

COLEC11, collectin subfamily member 11

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

COLEC11, collectin subfamily member 11
Synonyms

3MC2, CL-11, CLK1, CL-K1-I, CL-K1-II, CL-K1-IIa, CL-K1-IIb
Links

HGNC:17213

NCBI Gene ID: 78989

neXtProt AC: NX_Q9BWP8

UniProt: Q9BWP8
Chr Location

2p25.3

MGI Vertebrate Homology

Colec11 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: COLEC11
Gene Tree

Colec11

Diseases

1 with human COLEC11 associations

				Human Disease	Mouse Models
				3MC syndrome 2 IDs 3MC syndrome 2 DOID:0060576 OMIM:265050

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

3
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knockout allele exhibit decreased susceptibility to kidney reperfusion injury.

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All GO Annotations

26
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

721
Tissues

14
cDNA Data

8
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase colec11

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All Sequences

47
RefSeq

10
UniProt

4
CCDS

CCDS36426.1, CCDS88320.1

Ensembl

ENSMUSG00000036655 (Evidence)
NCBI Gene

71693

			Length	Strain/Species	Flank
genomic	ENSMUSG00000036655	Ensembl Gene Model \| MGI Sequence Detail	29205	C57BL/6J	± kb
transcript	ENSMUST00000220836	Ensembl \| MGI Sequence Detail	887	Not Applicable
polypeptide	ENSMUSP00000152876	Ensembl \| MGI Sequence Detail	278	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000005726 collectin-11

(term hierarchy)
InterPro Domains

IPR050801 Calcium-Dependent Lectins in Immunity and Development

IPR008160 Collagen triple helix repeat

IPR033990 Collectin, C-type lectin-like domain

IPR018378 C-type lectin, conserved site

IPR016187 C-type lectin fold

IPR001304 C-type lectin-like

IPR016186 C-type lectin-like/link domain superfamily

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All nucleic 9

cDNA 8

Other 1

Microarray probesets 4

Summaries

All 36

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:321979 Kurz J, et al., Notch signaling is a novel regulator of visceral smooth muscle cell differentiation in the murine ureter. Development. 2022 Feb 15;149(4):dev199735

TSS for Colec11:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr116013	Chr12:28673455-28673462 (-)	-83 bp
Tssr116012	Chr12:28673400-28673413 (-)	-31 bp
Tssr116011	Chr12:28673371-28673393 (-)	-6 bp
Tssr116010	Chr12:28673349-28673370 (-)	16 bp
Tssr116009	Chr12:28673334-28673345 (-)	36 bp
Tssr116008	Chr12:28673312-28673328 (-)	56 bp
Tssr116007	Chr12:28673281-28673295 (-)	88 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24