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Slc41a3 Gene Detail
Summary
  • Symbol
    Slc41a3
  • Name
    solute carrier family 41, member 3
  • Synonyms
    1010001P06Rik, SLC41A1-L2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918949
    NCBI Gene: 71699
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:90581707-90623394 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 40.16 cM, cytoband D2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    947 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918949
 protein coding gene Chr6:90579043-90623394 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031040
 protein coding gene Chr6:92151249-92192932 (+)
A/J MGP_AJ_G0031008
 protein coding gene Chr6:88640756-88682406 (+)
AKR/J MGP_AKRJ_G0030940
 protein coding gene Chr6:91114005-91155650 (+)
BALB/cJ MGP_BALBcJ_G0031020
 protein coding gene Chr6:88590775-88632479 (+)
C3H/HeJ MGP_C3HHeJ_G0030688
 protein coding gene Chr6:93290463-93332162 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031479
 protein coding gene Chr6:94573738-94616680 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0030127
 protein coding gene Chr6:91224013-91265669 (+)
CBA/J MGP_CBAJ_G0030706
 protein coding gene Chr6:98103464-98145401 (+)
DBA/2J MGP_DBA2J_G0030859
 protein coding gene Chr6:87832184-87873907 (+)
FVB/NJ MGP_FVBNJ_G0030813
 protein coding gene Chr6:87035622-87079004 (+)
LP/J MGP_LPJ_G0030939
 protein coding gene Chr6:92119497-92162493 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030847
 protein coding gene Chr6:102180302-102222001 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031506
 protein coding gene Chr6:90953142-90994796 (+)
PWK/PhJ MGP_PWKPhJ_G0029843
 protein coding gene Chr6:86776922-86818876 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029672
 protein coding gene Chr6:89856494-89899506 (+)
WSB/EiJ MGP_WSBEiJ_G0030211
 protein coding gene Chr6:91417378-91459096 (+)



Homology
more
  • Human Ortholog
    SLC41A3, solute carrier family 41 member 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC41A3, solute carrier family 41 member 3
  • Synonyms
    SLC41A1-L2
  • Links
    NCBI Gene ID: 54946
    neXtProt AC: NX_Q96GZ6
    UniProt: Q96GZ6

  • Chr Location
    3q21.2-q21.3; chr3:126006357-126101561 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit altered magnesium ion homeostasis including hypomagnesemia. A subset of homozygotes develop severe unilateral hydronephrosis when fed a low magnesium diet.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    917
  • Tissues
    96
  • cDNA Data
    15
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030089 Ensembl Gene Model | MGI Sequence Detail 41688 C57BL/6J ±  kb
    transcript ENSMUST00000044019 Ensembl | MGI Sequence Detail 2412 Not Applicable  
    polypeptide ENSMUSP00000037473 Ensembl | MGI Sequence Detail 488 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000029741 solute carrier family 41 member 3
      (term hierarchy)
    • InterPro Domains
      IPR045349 SLC41A divalent cation transporter
      IPR036739 SLC41A/MgtE divalent cation transporters, integral membrane domain superfamily
      IPR006667 SLC41A/MgtE, integral membrane domain
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 15
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2141427
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 12
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory