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Arhgef3 Gene Detail
Summary
  • Symbol
    Arhgef3
  • Name
    Rho guanine nucleotide exchange factor 3
  • Synonyms
    1200004I24Rik, 9830169H03Rik, C76747
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918954
    NCBI Gene: 71704
  • Alliance
    gene page
  • Transcription Start Sites
    26 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:26836856-27125868 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 16.09 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    8320 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918954
 protein coding gene Chr14:26836418-27125873 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021091
 protein coding gene Chr14:20246010-20418018 (+)
A/J MGP_AJ_G0021039
 protein coding gene Chr14:19445014-19619852 (+)
AKR/J MGP_AKRJ_G0021016
 protein coding gene Chr14:20506876-20680127 (+)
BALB/cJ MGP_BALBcJ_G0021043
 protein coding gene Chr14:19564514-19731000 (+)
C3H/HeJ MGP_C3HHeJ_G0020826
 protein coding gene Chr14:20367991-20536555 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021475
 protein coding gene Chr14:21087898-21265599 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019038
 protein coding gene Chr14:19573494-19741805 (+)
CAST/EiJ MGP_CASTEiJ_G0020351
 protein coding gene Chr14:19992880-20168522 (+)
CBA/J MGP_CBAJ_G0020793
 protein coding gene Chr14:21928060-22113090 (+)
DBA/2J MGP_DBA2J_G0020915
 protein coding gene Chr14:19527076-19694646 (+)
FVB/NJ MGP_FVBNJ_G0020899
 protein coding gene Chr14:19490577-19655294 (+)
LP/J MGP_LPJ_G0020984
 protein coding gene Chr14:20543183-20725037 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020925
 protein coding gene Chr14:21278710-21450200 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021508
 protein coding gene Chr14:20265402-20433720 (+)
PWK/PhJ MGP_PWKPhJ_G0020099
 protein coding gene Chr14:18939708-19112290 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019923
 protein coding gene Chr14:19764932-19929773 (+)
WSB/EiJ MGP_WSBEiJ_G0020406
 protein coding gene Chr14:20310788-20491191 (+)



Homology
more
  • Human Ortholog
    ARHGEF3, Rho guanine nucleotide exchange factor 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARHGEF3, Rho guanine nucleotide exchange factor 3
  • Synonyms
    GEF3, STA3, XPLN
  • Links
    NCBI Gene ID: 50650
    neXtProt AC: NX_Q9NR81
    UniProt: Q9NR81

  • Chr Location
    3p14.3; chr3:56727418-57079329 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one null allele exhibit increased mean platelet volume and a mild delay in platelet recovery in response to thrombocytopenia. Mice homozygous for another null allele display enhanced muscle regeneration and resistance to age-related decline in muscle function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    746
  • Tissues
    15
  • cDNA Data
    83
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021895 Ensembl Gene Model | MGI Sequence Detail 289013 C57BL/6J ±  kb
    transcript ENSMUST00000225949 Ensembl | MGI Sequence Detail 3198 Not Applicable  
    polypeptide ENSMUSP00000153396 Ensembl | MGI Sequence Detail 551 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 84
      cDNA 83
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1353572, MGI:2442908
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 4
      Gene Ontology 4
      Phenotypes 12
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:340100 You JS, et al., RhoA/ROCK signalling activated by ARHGEF3 promotes muscle weakness via autophagy in dystrophic mdx mice. J Cachexia Sarcopenia Muscle. 2023 Aug;14(4):1880-1893
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory