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Dram1 Gene Detail
Summary
  • Symbol
    Dram1
  • Name
    DNA-damage regulated autophagy modulator 1
  • Synonyms
    1200002N14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918962
    NCBI Gene: 71712
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:88158663-88200218 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 43.81 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1522 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918962
 protein coding gene Chr10:88158663-88214942 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017625
 protein coding gene Chr10:89399925-89463235 (-)
A/J MGP_AJ_G0017604
 protein coding gene Chr10:86382422-86439018 (-)
AKR/J MGP_AKRJ_G0017562
 protein coding gene Chr10:88844034-88899808 (-)
BALB/cJ MGP_BALBcJ_G0017567
 protein coding gene Chr10:86665158-86721700 (-)
C3H/HeJ MGP_C3HHeJ_G0017390
 protein coding gene Chr10:88816671-88877586 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018024
 protein coding gene Chr10:92405808-92474920 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015706
 protein coding gene Chr10:82149109-82207261 (-)
CAST/EiJ MGP_CASTEiJ_G0016955
 protein coding gene Chr10:88725609-88787105 (-)
CBA/J MGP_CBAJ_G0017359
 protein coding gene Chr10:96230104-96303679 (-)
DBA/2J MGP_DBA2J_G0017465
 protein coding gene Chr10:85501536-85558072 (-)
FVB/NJ MGP_FVBNJ_G0017457
 protein coding gene Chr10:84727408-84784765 (-)
LP/J MGP_LPJ_G0017539
 protein coding gene Chr10:90072030-90129900 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017488
 protein coding gene Chr10:97736979-97798516 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018061
 protein coding gene Chr10:88670629-88733791 (-)
PWK/PhJ MGP_PWKPhJ_G0016736
 protein coding gene Chr10:85517626-85577228 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016524
 protein coding gene Chr10:87405731-87475657 (-)
WSB/EiJ MGP_WSBEiJ_G0017014
 protein coding gene Chr10:88646425-88712114 (-)



Homology
more
  • Human Ortholog
    DRAM1, DNA damage regulated autophagy modulator 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DRAM1, DNA damage regulated autophagy modulator 1
  • Synonyms
    DRAM
  • Links
    NCBI Gene ID: 55332
    neXtProt AC: NX_Q8N682
    UniProt: Q8N682

  • Chr Location
    12q23.2; chr12:101877580-102012130 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    5
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    777
  • Tissues
    27
  • cDNA Data
    23
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 71712 NCBI Gene Model | MGI Sequence Detail 41556 C57BL/6J ±  kb
    transcript NM_001417838 RefSeq | MGI Sequence Detail 2842 C57BL/6  
    polypeptide Q9DC58 UniProt | EBI | MGI Sequence Detail 238 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 23
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 16
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory