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Dhx35 Gene Detail
Summary
  • Symbol
    Dhx35
  • Name
    DEAH-box helicase 35
  • Synonyms
    1200009D07Rik, Ddx35
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918965
    NCBI Gene: 71715
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:158636727-158700134 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 78.74 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2321 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918965
 protein coding gene Chr2:158636674-158700141 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026801
 protein coding gene Chr2:163893891-163964579 (+)
A/J MGP_AJ_G0026767
 protein coding gene Chr2:157316567-157379517 (+)
AKR/J MGP_AKRJ_G0026738
 protein coding gene Chr2:161941347-162006861 (+)
BALB/cJ MGP_BALBcJ_G0026776
 protein coding gene Chr2:157624299-157690024 (+)
C3H/HeJ MGP_C3HHeJ_G0026518
 protein coding gene Chr2:162291800-162357965 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027225
 protein coding gene Chr2:168769225-168834593 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024595
 protein coding gene Chr2:150751742-150813094 (+)
CAST/EiJ MGP_CASTEiJ_G0025980
 protein coding gene Chr2:162647505-162716345 (+)
CBA/J MGP_CBAJ_G0026495
 protein coding gene Chr2:174829191-174903712 (+)
DBA/2J MGP_DBA2J_G0026633
 protein coding gene Chr2:156498879-156561908 (+)
FVB/NJ MGP_FVBNJ_G0026600
 protein coding gene Chr2:154911670-154974533 (+)
LP/J MGP_LPJ_G0026736
 protein coding gene Chr2:163990235-164054458 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026621
 protein coding gene Chr2:178592987-178664675 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027281
 protein coding gene Chr2:161790201-161857735 (+)
PWK/PhJ MGP_PWKPhJ_G0025714
 protein coding gene Chr2:156033180-156098176 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025517
 protein coding gene Chr2:160707751-160775057 (+)
WSB/EiJ MGP_WSBEiJ_G0026050
 protein coding gene Chr2:162688264-162753895 (+)



Homology
more
  • Human Ortholog
    DHX35, DEAH-box helicase 35
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DHX35, DEAH-box helicase 35
  • Synonyms
    C20orf15, DDX35, KAIA0875
  • Links
    NCBI Gene ID: 60625
    neXtProt AC: NX_Q9H5Z1
    UniProt: Q9H5Z1

  • Chr Location
    20q11.23-q12; chr20:38962299-39039723 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit defects in placentation with abnormal trophoblast layer formation and complete lethality throughout fetal growth and development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    8
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027655 Ensembl Gene Model | MGI Sequence Detail 63408 C57BL/6J ±  kb
    transcript ENSMUST00000109478 Ensembl | MGI Sequence Detail 3284 Not Applicable  
    polypeptide ENSMUSP00000105104 Ensembl | MGI Sequence Detail 703 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • EC
      3.6.4.13
    • InterPro Domains
      IPR011709 DEAD-box helicase, OB fold
      IPR002464 DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site
      IPR007502 Helicase-associated domain
      IPR048333 Helicase associated domain (HA2), winged-helix domain
      IPR001650 Helicase, C-terminal domain-like
      IPR014001 Helicase superfamily 1/2, ATP-binding domain
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    • GlyGen
      A2ACQ1 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 8

      Microarray probesets 3
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 17
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:350444 Martinez-Mayer J, et al., Knockout mice with pituitary malformations help identify human cases of hypopituitarism. Genome Med. 2024 May 31;16(1):75
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory