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Osbpl3 Gene Detail
Summary
  • Symbol
    Osbpl3
  • Name
    oxysterol binding protein-like 3
  • Synonyms
    1200014M06Rik, 6720421I08Rik, ORP3, OSBP3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918970
    NCBI Gene: 71720
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:50270310-50433181 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 24.13 cM, cytoband B3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5288 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918970
 protein coding gene Chr6:50270307-50433334 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030729
 protein coding gene Chr6:49393831-49565192 (-)
A/J MGP_AJ_G0030700
 protein coding gene Chr6:47089330-47255375 (-)
AKR/J MGP_AKRJ_G0030625
 protein coding gene Chr6:48747512-48913318 (-)
BALB/cJ MGP_BALBcJ_G0030710
 protein coding gene Chr6:47431184-47598905 (-)
C3H/HeJ MGP_C3HHeJ_G0030423
 protein coding gene Chr6:48768371-48939131 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031165
 protein coding gene Chr6:50501182-50679844 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028372
 protein coding gene Chr6:44699521-44866330 (-)
CAST/EiJ MGP_CASTEiJ_G0029827
 protein coding gene Chr6:48478899-48647196 (-)
CBA/J MGP_CBAJ_G0030398
 protein coding gene Chr6:52629594-52813513 (-)
DBA/2J MGP_DBA2J_G0030547
 protein coding gene Chr6:47002490-47165890 (-)
FVB/NJ MGP_FVBNJ_G0030499
 protein coding gene Chr6:46642511-46806980 (-)
LP/J MGP_LPJ_G0030632
 protein coding gene Chr6:49341913-49524495 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030533
 protein coding gene Chr6:55338615-55518004 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031194
 protein coding gene Chr6:48661790-48831554 (-)
PWK/PhJ MGP_PWKPhJ_G0029539
 protein coding gene Chr6:46572959-46739164 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029375
 protein coding gene Chr6:47989052-48162010 (-)
WSB/EiJ MGP_WSBEiJ_G0029904
 protein coding gene Chr6:48626154-48798332 (-)



Homology
more
  • Human Ortholog
    OSBPL3, oxysterol binding protein like 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OSBPL3, oxysterol binding protein like 3
  • Synonyms
    ORP-3, ORP3, OSBP3
  • Links
    NCBI Gene ID: 26031
    neXtProt AC: NX_Q9H4L5
    UniProt: Q9H4L5

  • Chr Location
    7p15.3; chr7:24796537-24981845 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    894
  • Tissues
    42
  • cDNA Data
    14
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029822 Ensembl Gene Model | MGI Sequence Detail 162872 C57BL/6J ±  kb
    transcript ENSMUST00000090019 Ensembl | MGI Sequence Detail 4039 Not Applicable  
    polypeptide ENSMUSP00000087473 Ensembl | MGI Sequence Detail 886 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000012049 oxysterol-binding protein-related protein 3
      (term hierarchy)
    • InterPro Domains
      IPR000648 Oxysterol-binding protein
      IPR018494 Oxysterol-binding protein, conserved site
      IPR037239 Oxysterol-binding protein superfamily
      IPR011993 PH-like domain superfamily
      IPR051707 Phosphoinositide-Interacting Signal Transduction Regulators
      IPR001849 Pleckstrin homology domain
      IPR041680 Pleckstrin homology domain 8
    • GlyGen
      Q9DBS9 2 sites, 2 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 16
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1924397
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 3
      Gene Ontology 4
      Phenotypes 13
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory