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Vps11 Gene Detail
Summary
  • Symbol
    Vps11
  • Name
    VPS11, CORVET/HOPS core subunit
  • Synonyms
    1200011A11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918982
    NCBI Gene: 71732
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:44259046-44272967 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 24.84 cM, cytoband B
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    351 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918982
 protein coding gene Chr9:44259046-44272970 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034704
 protein coding gene Chr9:42834777-42852708 (-)
A/J MGP_AJ_G0034685
 protein coding gene Chr9:41643570-41657046 (-)
AKR/J MGP_AKRJ_G0034611
 protein coding gene Chr9:42502173-42519723 (-)
BALB/cJ MGP_BALBcJ_G0034676
 protein coding gene Chr9:41390226-41403624 (-)
C3H/HeJ MGP_C3HHeJ_G0034387
 protein coding gene Chr9:42962602-42976431 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035197
 protein coding gene Chr9:44106383-44122333 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032112
 protein coding gene Chr9:41221882-41237271 (-)
CAST/EiJ MGP_CASTEiJ_G0033709
 protein coding gene Chr9:42804657-42819489 (-)
CBA/J MGP_CBAJ_G0034359
 protein coding gene Chr9:45709653-45723117 (-)
DBA/2J MGP_DBA2J_G0034518
 protein coding gene Chr9:41546266-41559743 (-)
FVB/NJ MGP_FVBNJ_G0034459
 protein coding gene Chr9:40800393-40813923 (-)
LP/J MGP_LPJ_G0034599
 protein coding gene Chr9:43133764-43148161 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034503
 protein coding gene Chr9:47560000-47575252 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035218
 protein coding gene Chr9:42403898-42417305 (-)
PWK/PhJ MGP_PWKPhJ_G0033415
 protein coding gene Chr9:41415465-41429515 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033249
 protein coding gene Chr9:42723588-42737416 (-)
WSB/EiJ MGP_WSBEiJ_G0033822
 protein coding gene Chr9:42444229-42457692 (-)



Homology
more
  • Human Ortholog
    VPS11, VPS11 core subunit of CORVET and HOPS complexes
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VPS11, VPS11 core subunit of CORVET and HOPS complexes
  • Synonyms
    END1, HLD12, HLD12; DYT32, hVPS11, PEP5, RNF108
  • Links
    NCBI Gene ID: 55823
    neXtProt AC: NX_Q9H270
    UniProt: Q9H270

  • Chr Location
    11q23.3; chr11:119067818-119081972 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human VPS11 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    89
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032127 Ensembl Gene Model | MGI Sequence Detail 13922 C57BL/6J ±  kb
transcript ENSMUST00000034644 Ensembl | MGI Sequence Detail 3536 Not Applicable  
polypeptide ENSMUSP00000034644 Ensembl | MGI Sequence Detail 941 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000017318 vacuolar protein sorting-associated protein 11
    (term hierarchy)
  • InterPro Domains
    IPR016024 Armadillo-type fold
    IPR000547 Clathrin, heavy chain/VPS, 7-fold repeat
    IPR011990 Tetratricopeptide-like helical domain superfamily
    IPR016528 Vacuolar protein sorting-associated protein 11
    IPR024763 Vacuolar protein sorting protein 11, C-terminal
    IPR036322 WD40-repeat-containing domain superfamily
    IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    IPR013083 Zinc finger, RING/FYVE/PHD-type
    IPR001841 Zinc finger, RING-type
Molecular
Reagents
less
  • All nucleic 89
    cDNA 89

    Microarray probesets 6
References
more
  • Summaries
    All 43
    Developmental Gene Expression 1
    Gene Ontology 11
    Phenotypes 10
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory