Ulk3 MGI Mouse Gene Detail - MGI:1918992

Symbol

Ulk3
Name

unc-51-like kinase 3
Synonyms

1200015E14Rik

Feature Type

protein coding gene
IDs

MGI:1918992
NCBI Gene: 71742
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr9:57496735-57503516 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 31.09 cM, cytoband C
Mapping Data

2 experiments

SNPs within 2kb

214 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918992	protein coding gene	Chr9:57496423-57503516 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034871	protein coding gene	Chr9:56809443-56816215 (+)
A/J	MGP_AJ_G0034852	protein coding gene	Chr9:54975685-54982556 (+)
AKR/J	MGP_AKRJ_G0034781	protein coding gene	Chr9:56236500-56243186 (+)
BALB/cJ	MGP_BALBcJ_G0034844	protein coding gene	Chr9:54760622-54767399 (+)
C3H/HeJ	MGP_C3HHeJ_G0034554	protein coding gene	Chr9:56723516-56730327 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035363	protein coding gene	Chr9:58390118-58396894 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032274	protein coding gene	Chr9:54278542-54285446 (+)
CAST/EiJ	MGP_CASTEiJ_G0033875	protein coding gene	Chr9:56812493-56819220 (+)
CBA/J	MGP_CBAJ_G0034525	protein coding gene	Chr9:60424454-60431196 (+)
DBA/2J	MGP_DBA2J_G0034684	protein coding gene	Chr9:54842921-54850134 (+)
FVB/NJ	MGP_FVBNJ_G0034626	protein coding gene	Chr9:54070543-54077264 (+)
LP/J	MGP_LPJ_G0034767	protein coding gene	Chr9:57102960-57109695 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034669	protein coding gene	Chr9:61927203-61933846 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035385	protein coding gene	Chr9:56259885-56266700 (+)
PWK/PhJ	MGP_PWKPhJ_G0033580	protein coding gene	Chr9:54872737-54879469 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033414	protein coding gene	Chr9:56553687-56560205 (+)
WSB/EiJ	MGP_WSBEiJ_G0033988	protein coding gene	Chr9:56194805-56201575 (+)

Human Ortholog

ULK3, unc-51 like kinase 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ULK3, unc-51 like kinase 3
Links

HGNC:19703

NCBI Gene ID: 25989

neXtProt AC: NX_Q6PHR2

UniProt: Q6PHR2
Chr Location

15q24.1; chr15:74836118-74843346 (-) GRCh38

MGI Vertebrate Homology

Ulk3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ULK3
Gene Tree

Ulk3

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Phenotype Summary

12 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

51
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

710
Tissues

1
cDNA Data

20
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ulk3

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All Sequences

60
RefSeq

19
UniProt

2
CCDS

CCDS52809.1

Ensembl

ENSMUSG00000032308 (Evidence)
NCBI Gene

71742

			Length	Strain/Species	Flank
genomic	ENSMUSG00000032308	Ensembl Gene Model \| MGI Sequence Detail	6782	C57BL/6J	± kb
transcript	ENSMUST00000053230	Ensembl \| MGI Sequence Detail	2826	Not Applicable
polypeptide	ENSMUSP00000059947	Ensembl \| MGI Sequence Detail	472	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000017079 serine/threonine-protein kinase ULK3

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR007330 MIT domain

IPR036181 MIT domain superfamily

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

IPR045269 Serine/threonine-protein kinase Atg1-like

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All nucleic 21

cDNA 20

Primer pair 1

Microarray probesets 2

Summaries

All 35

Developmental Gene Expression 1

Gene Ontology 10

Phenotypes 6
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ulk3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr85316	Chr9:57496725-57496765 (+)	10 bp
Tssr85317	Chr9:57496768-57496781 (+)	40 bp
Tssr85318	Chr9:57496791-57496849 (+)	85 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24