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Rgl3 Gene Detail
Summary
  • Symbol
    Rgl3
  • Name
    ral guanine nucleotide dissociation stimulator-like 3
  • Synonyms
    1300003D20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918996
    NCBI Gene: 71746
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:21882475-21900765 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 7.96 cM, cytoband A4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    565 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918996
 protein coding gene Chr9:21880007-21900765 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034471
 protein coding gene Chr9:19245594-19264830 (-)
A/J MGP_AJ_G0034449
 protein coding gene Chr9:18875708-18893598 (-)
AKR/J MGP_AKRJ_G0034375
 protein coding gene Chr9:19241895-19259849 (-)
BALB/cJ MGP_BALBcJ_G0034440
 protein coding gene Chr9:18757078-18775447 (-)
C3H/HeJ MGP_C3HHeJ_G0034152
 protein coding gene Chr9:19536915-19559915 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034961
 protein coding gene Chr9:20002024-20019864 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031891
 protein coding gene Chr9:17975527-17993647 (-)
CAST/EiJ MGP_CASTEiJ_G0033475
 protein coding gene Chr9:19380101-19398562 (-)
CBA/J MGP_CBAJ_G0034125
 protein coding gene Chr9:20791941-20809827 (-)
DBA/2J MGP_DBA2J_G0034283
 protein coding gene Chr9:18838913-18857057 (-)
FVB/NJ MGP_FVBNJ_G0034226
 protein coding gene Chr9:18388483-18406345 (-)
LP/J MGP_LPJ_G0034369
 protein coding gene Chr9:19395046-19413969 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034270
 protein coding gene Chr9:22345653-22368021 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034981
 protein coding gene Chr9:19200874-19219926 (-)
PWK/PhJ MGP_PWKPhJ_G0033180
 protein coding gene Chr9:18843728-18862699 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033014
 protein coding gene Chr9:19243881-19265659 (-)
WSB/EiJ MGP_WSBEiJ_G0033590
 protein coding gene Chr9:18930738-18948636 (-)



Homology
more
  • Human Ortholog
    RGL3, ral guanine nucleotide dissociation stimulator like 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RGL3, ral guanine nucleotide dissociation stimulator like 3
  • Links
    NCBI Gene ID: 57139
    neXtProt AC: NX_Q3MIN7
    UniProt: Q3MIN7

  • Chr Location
    19p13.2; chr19:11384341-11419328 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    8
  • cDNA Data
    29
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 71746 NCBI Gene Model | MGI Sequence Detail 18291 C57BL/6J ±  kb
    transcript NM_023622 RefSeq | MGI Sequence Detail 2891 C57BL/6  
    polypeptide Q3UYI5 UniProt | EBI | MGI Sequence Detail 709 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000013938 Ral guanine nucleotide dissociation stimulator-like 3
      (term hierarchy)
    • InterPro Domains
      IPR030750 Ral guanine nucleotide dissociation stimulator-like 3, RA domain
      IPR000159 Ras-associating domain
      IPR036964 Ras guanine-nucleotide exchange factor, catalytic domain superfamily
      IPR019804 Ras guanine-nucleotide exchange factor, conserved site
      IPR023578 Ras guanine nucleotide exchange factor domain superfamily
      IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
      IPR008937 Ras-like guanine nucleotide exchange factor
      IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
      IPR029071 Ubiquitin-like domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 29
      cDNA 29

      Microarray probesets 2
    References
    more
    • Summaries
      All 26
      Developmental Gene Expression 1
      Gene Ontology 2
      Phenotypes 7
    • Earliest
      J:64313 Shao H, et al., A novel RalGEF-like protein, RGL3, as a candidate effector for rit and Ras. J Biol Chem. 2000 Sep 1;275(35):26914-24
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory