Tysnd1 MGI Mouse Gene Detail - MGI:1919017 - trypsin domain containing 1

Symbol

Tysnd1
Name

trypsin domain containing 1
Synonyms

1300019N10Rik

Feature Type

protein coding gene
IDs

MGI:1919017
NCBI Gene: 71767
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr10:61531293-61538552 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 32.26 cM, cytoband B4
Mapping Data

3 experiments

SNPs within 2kb

256 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919017	protein coding gene	Chr10:61531279-61538552 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017286	protein coding gene	Chr10:61056939-61065693 (+)
A/J	MGP_AJ_G0017264	protein coding gene	Chr10:59223936-59231198 (+)
AKR/J	MGP_AKRJ_G0017224	protein coding gene	Chr10:60768993-60776257 (+)
BALB/cJ	MGP_BALBcJ_G0017224	protein coding gene	Chr10:59299707-59306908 (+)
C3H/HeJ	MGP_C3HHeJ_G0017047	protein coding gene	Chr10:60671554-60678931 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017682	protein coding gene	Chr10:63242765-63253395 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015373	protein coding gene	Chr10:56201664-56209073 (+)
CAST/EiJ	MGP_CASTEiJ_G0016618	protein coding gene	Chr10:60690606-60700628 (+)
CBA/J	MGP_CBAJ_G0017019	protein coding gene	Chr10:65605986-65613196 (+)
DBA/2J	MGP_DBA2J_G0017124	protein coding gene	Chr10:58495184-58502355 (+)
FVB/NJ	MGP_FVBNJ_G0017118	protein coding gene	Chr10:57746847-57754085 (+)
LP/J	MGP_LPJ_G0017199	protein coding gene	Chr10:61455737-61464168 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017146	protein coding gene	Chr10:67902778-67911052 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017720	protein coding gene	Chr10:60594941-60603364 (+)
PWK/PhJ	MGP_PWKPhJ_G0016401	protein coding gene	Chr10:58342383-58349814 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016184	protein coding gene	Chr10:59952405-59962414 (+)
WSB/EiJ	MGP_WSBEiJ_G0016682	protein coding gene	Chr10:60509699-60518031 (+)

Human Ortholog

TYSND1, trypsin like peroxisomal matrix peptidase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TYSND1, trypsin like peroxisomal matrix peptidase 1
Synonyms

NET41
Links

HGNC:28531

NCBI Gene ID: 219743

neXtProt AC: NX_Q2T9J0

UniProt: Q2T9J0
Chr Location

10q22.1; chr10:70137981-70146700 (-) GRCh38

MGI Vertebrate Homology

Tysnd1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TYSND1
Protein SuperFamily

Peptidase_S1B_Tysnd1
Gene Tree

Tysnd1

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Phenotype Summary

16 phenotypes from 1 allele in 1 genetic background
2 images
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Tysnd1
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit male infertility with globozoospermia, hypoactivity, absence acrosomal cap, indicators of liver damage, abnormal hepatocyte peroxisomes and autophagosomes and enlarged, beige livers.

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All GO Annotations

18
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

58

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tysnd1

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All Sequences

60
RefSeq

10
UniProt

4
CCDS

CCDS48575.1

Ensembl

ENSMUSG00000020087 (Evidence)
NCBI Gene

71767

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020087	Ensembl Gene Model \| MGI Sequence Detail	7260	C57BL/6J	± kb
transcript	ENSMUST00000020284	Ensembl \| MGI Sequence Detail	2286	Not Applicable
polypeptide	ENSMUSP00000020284	Ensembl \| MGI Sequence Detail	568	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000016881 peroxisomal leader peptide-processing protease

(term hierarchy)
EC

3.4.21.-
InterPro Domains

IPR017345 Peptidase S1A, Tysnd1

IPR009003 Peptidase S1, PA clan

IPR043504 Peptidase S1, PA clan, chymotrypsin-like fold

IPR039245 Peroxisomal/glyoxysomal leader peptide-processing protease

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All nucleic 58

cDNA 58

Microarray probesets 7

Summaries

All 34

Gene Ontology 5

Phenotypes 8
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:223054 Mizuno Y, et al., Tysnd1 deficiency in mice interferes with the peroxisomal localization of PTS2 enzymes, causing lipid metabolic abnormalities and male infertility. PLoS Genet. 2013;9(2):e1003286

TSS for Tysnd1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr93676	Chr10:61531282-61531355 (+)	26 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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