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Ing3 Gene Detail
Summary
  • Symbol
    Ing3
  • Name
    inhibitor of growth family, member 3
  • Synonyms
    1300013A07Rik, P47ING3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919027
    NCBI Gene: 71777
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:21949570-21976037 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 8.81 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    658 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919027
 protein coding gene Chr6:21948002-21976037 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030481
 protein coding gene Chr6:19419618-19445946 (+)
A/J MGP_AJ_G0030454
 protein coding gene Chr6:18634443-18660808 (+)
AKR/J MGP_AKRJ_G0030381
 protein coding gene Chr6:19221309-19247688 (+)
BALB/cJ MGP_BALBcJ_G0030463
 protein coding gene Chr6:18708591-18735252 (+)
C3H/HeJ MGP_C3HHeJ_G0030177
 protein coding gene Chr6:19171248-19200029 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030918
 protein coding gene Chr6:20012208-20040028 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028129
 protein coding gene Chr6:17249056-17276383 (+)
CAST/EiJ MGP_CASTEiJ_G0029579
 protein coding gene Chr6:19092458-19118562 (+)
CBA/J MGP_CBAJ_G0030155
 protein coding gene Chr6:20674541-20702580 (+)
DBA/2J MGP_DBA2J_G0030299
 protein coding gene Chr6:18530624-18560253 (+)
FVB/NJ MGP_FVBNJ_G0030253
 protein coding gene Chr6:18331033-18360574 (+)
LP/J MGP_LPJ_G0030386
 protein coding gene Chr6:19519192-19550120 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030289
 protein coding gene Chr6:22519102-22545411 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030948
 protein coding gene Chr6:19167887-19195691 (+)
PWK/PhJ MGP_PWKPhJ_G0029293
 protein coding gene Chr6:18214777-18241595 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029129
 protein coding gene Chr6:18923998-18950762 (+)
WSB/EiJ MGP_WSBEiJ_G0029655
 protein coding gene Chr6:19054147-19081977 (+)



Homology
more
  • Human Ortholog
    ING3, inhibitor of growth family member 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ING3, inhibitor of growth family member 3
  • Synonyms
    Eaf4, ING2, MEAF4, p47ING3
  • Links
    NCBI Gene ID: 54556
    neXtProt AC: NX_Q9NXR8
    UniProt: Q9NXR8

  • Chr Location
    7q31.31; chr7:120950763-120977216 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    13 phenotype references
Mice homozygous for a transgene disruption of the gene exhibit abnormal embryonic development and brain formation with lethality between E10.5 and birth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    794
  • Tissues
    64
  • cDNA Data
    57
  • Literature Summary
    9
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029670 Ensembl Gene Model | MGI Sequence Detail 26468 C57BL/6J ±  kb
transcript ENSMUST00000031680 Ensembl | MGI Sequence Detail 3800 Not Applicable  
polypeptide ENSMUSP00000031680 Ensembl | MGI Sequence Detail 421 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 60
    cDNA 57
    Primer pair 2
    Other 1

    Microarray probesets 7
References
more
  • Summaries
    All 50
    Developmental Gene Expression 9
    Gene Ontology 9
    Phenotypes 13
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:328727 Rodriguez AB, et al., Immune mechanisms orchestrate tertiary lymphoid structures in tumors via cancer-associated fibroblasts. Cell Rep. 2021 Jul 20;36(3):109422
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory