Klhl5 MGI Mouse Gene Detail - MGI:1919028

Symbol

Klhl5
Name

kelch-like 5
Synonyms

1300013C10Rik

Feature Type

protein coding gene
IDs

MGI:1919028
NCBI Gene: 71778
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr5:65264894-65325490 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 33.58 cM
Mapping Data

1 experiment

SNPs within 2kb

1721 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919028	protein coding gene	Chr5:65264882-65325531 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029572	protein coding gene	Chr5:64750486-64787798 (+)
A/J	MGP_AJ_G0029540	protein coding gene	Chr5:62352074-62389144 (+)
AKR/J	MGP_AKRJ_G0029488	protein coding gene	Chr5:64322059-64359104 (+)
BALB/cJ	MGP_BALBcJ_G0029549	protein coding gene	Chr5:63035900-63072928 (+)
C3H/HeJ	MGP_C3HHeJ_G0029272	protein coding gene	Chr5:64668232-64705224 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030003	protein coding gene	Chr5:67433210-67470133 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027243	protein coding gene	Chr5:58416664-58453738 (+)
CAST/EiJ	MGP_CASTEiJ_G0028680	protein coding gene	Chr5:63766962-63804162 (+)
CBA/J	MGP_CBAJ_G0029241	protein coding gene	Chr5:69611774-69654094 (+)
DBA/2J	MGP_DBA2J_G0029387	protein coding gene	Chr5:62365615-62403633 (+)
FVB/NJ	MGP_FVBNJ_G0029347	protein coding gene	Chr5:61558400-61595502 (+)
LP/J	MGP_LPJ_G0029472	protein coding gene	Chr5:65238718-65275800 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029375	protein coding gene	Chr5:72491710-72531121 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030036	protein coding gene	Chr5:64001126-64038289 (+)
PWK/PhJ	MGP_PWKPhJ_G0028404	protein coding gene	Chr5:61341784-61380341 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028238	protein coding gene	Chr5:63310350-63348915 (+)
WSB/EiJ	MGP_WSBEiJ_G0028760	protein coding gene	Chr5:64200940-64239198 (+)

Human Ortholog

KLHL5, kelch like family member 5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KLHL5, kelch like family member 5
Links

HGNC:6356

NCBI Gene ID: 51088

neXtProt AC: NX_Q96PQ7

UniProt: Q96PQ7
Chr Location

4p14

MGI Vertebrate Homology

Klhl5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: KLHL5
Protein SuperFamily

Kelch-like_protein_gigaxonin
Gene Tree

Klhl5

Diseases

1 with human KLHL5 associations

				Human Disease	Mouse Models
				cocaine dependence IDs cocaine dependence DOID:9975 ICD10CM:F14.2 ICD9CM:304.2 ICD9CM:304.20 MESH:D019970 NCI:C34492 UMLS_CUI:C0600427

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
25 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

1
Radiation induced

1
Spontaneous

1
Targeted

3
Genomic Mutations

4 involving Klhl5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

43 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

4
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

914
Tissues

79
cDNA Data

71
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase klhl5

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All Sequences

75
RefSeq

12
UniProt

7
CCDS

CCDS19305.2, CCDS84883.1

Ensembl

ENSMUSG00000054920 (Evidence)
NCBI Gene

71778

			Length	Strain/Species	Flank
genomic	71778	NCBI Gene Model \| MGI Sequence Detail	60597	C57BL/6J	± kb
transcript	NM_175174	RefSeq \| MGI Sequence Detail	3422	C57BL/6
polypeptide	NP_780383	RefSeq \| MGI Sequence Detail	708	C57BL/6

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UniProt

7 Sequences
InterPro Domains

IPR011705 BTB/Kelch-associated

IPR017096 BTB-kelch protein

IPR000210 BTB/POZ domain

IPR037293 Galactose oxidase, central domain superfamily

IPR030606 Kelch-like protein 5, BTB/POZ domain

IPR006652 Kelch repeat type 1

IPR015915 Kelch-type beta propeller

IPR011333 SKP1/BTB/POZ domain superfamily

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All nucleic 71

cDNA 71

Microarray probesets 4

Summaries

All 47

Developmental Gene Expression 5

Gene Ontology 1

Phenotypes 25
Earliest

J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Klhl5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr46442	Chr5:65264894-65264925 (+)	16 bp
Tssr46443	Chr5:65264938-65264956 (+)	53 bp
Tssr46444	Chr5:65264956-65264959 (+)	64 bp
Tssr46445	Chr5:65264961-65264998 (+)	86 bp
Tssr46446	Chr5:65265001-65265008 (+)	111 bp
Tssr46447	Chr5:65272286-65272293 (+)	7,396 bp
Tssr46448	Chr5:65288342-65288353 (+)	23,454 bp
Tssr46449	Chr5:65288452-65288501 (+)	23,583 bp
Tssr46450	Chr5:65288527-65288557 (+)	23,648 bp
Tssr46452	Chr5:65312322-65312333 (+)	47,434 bp
Tssr46453	Chr5:65312438-65312446 (+)	47,548 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24