Slc25a18 MGI Mouse Gene Detail - MGI:1919053 - solute carrier family 25 (mitochondrial carrier), member 18

Symbol

Slc25a18
Name

solute carrier family 25 (mitochondrial carrier), member 18
Synonyms

1500015I14Rik

Feature Type

protein coding gene
IDs

MGI:1919053
NCBI Gene: 71803
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr6:120750539-120771297 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 57.00 cM
Mapping Data

3 experiments

SNPs within 2kb

191 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919053	protein coding gene	Chr6:120750527-120771297 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031208	protein coding gene	Chr6:123685813-123710978 (+)
A/J	MGP_AJ_G0031177	protein coding gene	Chr6:118932024-118952552 (+)
AKR/J	MGP_AKRJ_G0031108	protein coding gene	Chr6:122147220-122167801 (+)
BALB/cJ	MGP_BALBcJ_G0031188	protein coding gene	Chr6:118691798-118712201 (+)
C3H/HeJ	MGP_C3HHeJ_G0030521	protein coding gene	Chr6:62149911-62170418 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031646	protein coding gene	Chr6:126853628-126881305 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028806	protein coding gene	Chr6:115828892-115850289 (+)
CAST/EiJ	MGP_CASTEiJ_G0030295	protein coding gene	Chr6:122594947-122615679 (+)
CBA/J	MGP_CBAJ_G0030871	protein coding gene	Chr6:131889141-131914511 (+)
DBA/2J	MGP_DBA2J_G0031027	protein coding gene	Chr6:117813723-117837649 (+)
FVB/NJ	MGP_FVBNJ_G0030979	protein coding gene	Chr6:116948336-116971992 (+)
LP/J	MGP_LPJ_G0031106	protein coding gene	Chr6:123681464-123702553 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031013	protein coding gene	Chr6:135868225-135890612 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031675	protein coding gene	Chr6:122163594-122186659 (+)
PWK/PhJ	MGP_PWKPhJ_G0030010	protein coding gene	Chr6:116860161-116879981 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029839	protein coding gene	Chr6:120907564-120931218 (+)
WSB/EiJ	MGP_WSBEiJ_G0030378	protein coding gene	Chr6:122450677-122475215 (+)

Human Ortholog

SLC25A18, solute carrier family 25 member 18

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC25A18, solute carrier family 25 member 18
Synonyms

GC2
Links

HGNC:10988

NCBI Gene ID: 83733

neXtProt AC: NX_Q9H1K4

UniProt: Q9H1K4
Chr Location

22q11.21; chr22:17563450-17590995 (+) GRCh38

MGI Vertebrate Homology

Slc25a18 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC25A18
Gene Tree

Slc25a18

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Phenotype Summary

18 phenotypes from 2 alleles in 2 genetic backgrounds
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

1
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

13
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

11

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc25a18

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All Sequences

37
RefSeq

8
UniProt

1
CCDS

CCDS39614.1

Ensembl

ENSMUSG00000004902 (Evidence)
NCBI Gene

71803

			Length	Strain/Species	Flank
genomic	ENSMUSG00000004902	Ensembl Gene Model \| MGI Sequence Detail	20759	C57BL/6J	± kb
transcript	ENSMUST00000112682	Ensembl \| MGI Sequence Detail	1911	Not Applicable
polypeptide	ENSMUSP00000108302	Ensembl \| MGI Sequence Detail	320	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000015013 mitochondrial glutamate carrier 2

(term hierarchy)
InterPro Domains

IPR023395 Mitochondrial carrier domain superfamily

IPR002067 Mitochondrial carrier protein

IPR051028 Mitochondrial Solute Carrier

IPR018108 Mitochondrial substrate/solute carrier
GlyGen

Q9DB41 1 site, 1 N-linked glycan (1 site)

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All nucleic 12

cDNA 11

Primer pair 1

Microarray probesets 3

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MGI:2141654

Summaries

All 32

Gene Ontology 6

Phenotypes 7
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Slc25a18:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr58547	Chr6:120750510-120750540 (+)	-14 bp
Tssr58548	Chr6:120750545-120750547 (+)	7 bp
Tssr58549	Chr6:120750553-120750558 (+)	17 bp
Tssr58550	Chr6:120750572-120750585 (+)	40 bp
Tssr58551	Chr6:120750594-120750597 (+)	57 bp
Tssr58552	Chr6:120753472-120753494 (+)	2,944 bp
Tssr58553	Chr6:120771024-120771030 (+)	20,488 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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