Csl MGI Mouse Gene Detail - MGI:1919082

Symbol

Csl
Name

citrate synthase like
Synonyms

1700007H16Rik

Feature Type

protein coding gene
IDs

MGI:1919082
NCBI Gene: 71832
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr10:99593567-99595346 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 51.20 cM, cytoband C3
Mapping Data

2 experiments

SNPs within 2kb

160 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919082	protein coding gene	Chr10:99593567-99595520 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017688	protein coding gene	Chr10:101601827-101603780 (-)
A/J	MGP_AJ_G0017667	protein coding gene	Chr10:97910523-97912476 (-)
AKR/J	MGP_AKRJ_G0017627	protein coding gene	Chr10:100709701-100711657 (-)
BALB/cJ	MGP_BALBcJ_G0017631	protein coding gene	Chr10:98219512-98221465 (-)
C3H/HeJ	MGP_C3HHeJ_G0017454	protein coding gene	Chr10:100737213-100739204 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018087	protein coding gene	Chr10:105130519-105132472 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015767	protein coding gene	Chr10:93321703-93323663 (-)
CAST/EiJ	MGP_CASTEiJ_G0017017	protein coding gene	Chr10:100824377-100827450 (-)
CBA/J	MGP_CBAJ_G0017423	protein coding gene	Chr10:109204098-109206058 (-)
DBA/2J	MGP_DBA2J_G0017529	protein coding gene	Chr10:96997480-96999433 (-)
FVB/NJ	MGP_FVBNJ_G0017522	protein coding gene	Chr10:96202400-96204553 (-)
LP/J	MGP_LPJ_G0017603	protein coding gene	Chr10:102189378-102191331 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017552	protein coding gene	Chr10:110466392-110468342 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018125	protein coding gene	Chr10:100675137-100677090 (-)
PWK/PhJ	MGP_PWKPhJ_G0016799	protein coding gene	Chr10:97126287-97128356 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016588	protein coding gene	Chr10:99546875-99548834 (-)
WSB/EiJ	MGP_WSBEiJ_G0017077	protein coding gene	Chr10:100642372-100644317 (-)

Human Ortholog

CS, citrate synthase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CS, citrate synthase
Links

HGNC:2422

NCBI Gene ID: 1431

neXtProt AC: NX_O75390

UniProt: O75390
Chr Location

12q13.3; chr12:56271699-56300391 (-) GRCh38

MGI Vertebrate Homology

Csl stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CS
Gene Tree

Csl

Diseases

2 with human CS associations

				Human Disease	Mouse Models
				dilated cardiomyopathy IDs dilated cardiomyopathy DOID:12930 EFO:0000407 ICD10CM:I42.0 KEGG:05414 MESH:D002311 NCI:C84673 OMIM:PS115200 ORDO:217604 UMLS_CUI:C0007193
				hypertrophic cardiomyopathy IDs hypertrophic cardiomyopathy DOID:11984 DOID:11986 ICD9CM:425.1 ICD9CM:425.11 KEGG:05410 MESH:D002312 NCI:C34449 ORDO:217569 UMLS_CUI:C0007194

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Chemically induced (other)

1
Gene trapped

1
Targeted

1
Genomic Mutations

1 involving Csl
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Male mice homozygous for a knock-out allele are initially fertile but show an age-dependent decline in fertility and a delay in the first spike of Ca²⁺ oscillation during egg activation.

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All GO Annotations

14
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

841
Tissues

97
cDNA Data

9
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

29
RefSeq

2
UniProt

2
CCDS

CCDS24149.1

Ensembl

ENSMUSG00000046934 (Evidence)
NCBI Gene

71832

			Length	Strain/Species	Flank
genomic	71832	NCBI Gene Model \| MGI Sequence Detail	1780	C57BL/6J	± kb
transcript	NM_027945	RefSeq \| MGI Sequence Detail	1780	C57BL/6
polypeptide	NP_082221	RefSeq \| MGI Sequence Detail	466	C57BL/6

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UniProt

2 Sequences
InterPro Domains

IPR002020 Citrate synthase

IPR019810 Citrate synthase active site

IPR010109 Citrate synthase, eukaryotic-type

IPR016142 Citrate synthase-like, large alpha subdomain

IPR016143 Citrate synthase-like, small alpha subdomain

IPR036969 Citrate synthase superfamily
GlyGen

Q80X68 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)

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All nucleic 9

cDNA 9

Microarray probesets 2

Summaries

All 37

Developmental Gene Expression 3

Gene Ontology 4

Phenotypes 13
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:351169 Fukuoka M, et al., Overdue Calcium Oscillation Causes Polyspermy but Possibly Permits Normal Development in Mouse Eggs. Int J Mol Sci. 2023 Dec 24;25(1)

TSS for Csl:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr99137	Chr10:99595525-99595536 (-)	-185 bp
Tssr99136	Chr10:99595498-99595514 (-)	-160 bp
Tssr99135	Chr10:99595480-99595491 (-)	-140 bp
Tssr99134	Chr10:99595467-99595478 (-)	-127 bp
Tssr99133	Chr10:99595455-99595463 (-)	-113 bp
Tssr99132	Chr10:99595365-99595375 (-)	-24 bp
Tssr99131	Chr10:99595337-99595354 (-)	0 bp
Tssr99130	Chr10:99595312-99595331 (-)	24 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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