Dcaf7 MGI Mouse Gene Detail - MGI:1919083 - DDB1 and CUL4 associated factor 7

Symbol

Dcaf7
Name

DDB1 and CUL4 associated factor 7
Synonyms

1700012F10Rik, 2610037L01Rik, Wdr68

Feature Type

protein coding gene
IDs

MGI:1919083
NCBI Gene: 71833
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr11:105927698-105950150 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 68.89 cM, cytoband E1
Mapping Data

3 experiments

SNPs within 2kb

586 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919083	protein coding gene	Chr11:105927698-105950150 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019291	protein coding gene	Chr11:109302086-109328512 (+)
A/J	MGP_AJ_G0019259	protein coding gene	Chr11:104653378-104676962 (+)
AKR/J	MGP_AKRJ_G0019228	protein coding gene	Chr11:107782077-107804587 (+)
BALB/cJ	MGP_BALBcJ_G0019233	protein coding gene	Chr11:105057292-105081691 (+)
C3H/HeJ	MGP_C3HHeJ_G0019042	protein coding gene	Chr11:108072304-108095754 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019683	protein coding gene	Chr11:112661880-112684339 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017308	protein coding gene	Chr11:101943464-101965512 (+)
CAST/EiJ	MGP_CASTEiJ_G0018595	protein coding gene	Chr11:109123792-109146120 (+)
CBA/J	MGP_CBAJ_G0019011	protein coding gene	Chr11:117345021-117372655 (+)
DBA/2J	MGP_DBA2J_G0019123	protein coding gene	Chr11:104127730-104151361 (+)
FVB/NJ	MGP_FVBNJ_G0019114	protein coding gene	Chr11:103632300-103654687 (+)
LP/J	MGP_LPJ_G0019193	protein coding gene	Chr11:109754964-109779627 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019144	protein coding gene	Chr11:116642851-116665288 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019720	protein coding gene	Chr11:108260453-108283133 (+)
PWK/PhJ	MGP_PWKPhJ_G0018360	protein coding gene	Chr11:105221321-105245324 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018151	protein coding gene	Chr11:108035603-108059267 (+)
WSB/EiJ	MGP_WSBEiJ_G0018646	protein coding gene	Chr11:108233681-108259537 (+)

Human Ortholog

DCAF7, DDB1 and CUL4 associated factor 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DCAF7, DDB1 and CUL4 associated factor 7
Synonyms

AN11, HAN11, SWAN-1, WDR68
Links

HGNC:30915

NCBI Gene ID: 10238

neXtProt AC: NX_P61962

UniProt: P61962
Chr Location

17q23.3; chr17:63550222-63594286 (+) GRCh38

MGI Vertebrate Homology

Dcaf7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DCAF7
Gene Tree

Dcaf7

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

4
Gene trapped

4
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

13
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

723
Tissues

15
cDNA Data

17
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dcaf7

ZFIN dcaf7

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All Sequences

54
RefSeq

2
UniProt

3
CCDS

CCDS25546.1

Ensembl

ENSMUSG00000049354 (Evidence)
NCBI Gene

71833

			Length	Strain/Species	Flank
genomic	71833	NCBI Gene Model \| MGI Sequence Detail	22453	C57BL/6J	± kb
transcript	NM_027946	RefSeq \| MGI Sequence Detail	5765	C57BL/6
polypeptide	P61963	UniProt \| EBI \| MGI Sequence Detail	342	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000029377 DDB1- and CUL4-associated factor 7

(term hierarchy)
InterPro Domains

IPR001680 WD40 repeat

IPR019775 WD40 repeat, conserved site

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily

IPR045159 WD repeat-containing protein DCAF7-like
GlyGen

P61963 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 18

cDNA 17

Primer pair 1

Microarray probesets 7

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MGI:1922876, MGI:2144685

Summaries

All 44

Developmental Gene Expression 6

Gene Ontology 5

Phenotypes 11
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dcaf7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105478	Chr11:105927683-105927692 (+)	-10 bp
Tssr105479	Chr11:105927693-105927750 (+)	24 bp
Tssr105480	Chr11:105927754-105927771 (+)	65 bp
Tssr105481	Chr11:105927786-105927798 (+)	94 bp
Tssr105482	Chr11:105945710-105945744 (+)	18,029 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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