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Phf7 Gene Detail
Summary
  • Symbol
    Phf7
  • Name
    PHD finger protein 7
  • Synonyms
    1700006H01Rik, 1700010P14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919088
    NCBI Gene: 71838
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:30959646-30973274 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 19.09 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    384 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919088
 protein coding gene Chr14:30959646-30973327 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021124
 protein coding gene Chr14:24413743-24427268 (-)
A/J MGP_AJ_G0021072
 protein coding gene Chr14:23491240-23504787 (-)
AKR/J MGP_AKRJ_G0021049
 protein coding gene Chr14:24615234-24628745 (-)
BALB/cJ MGP_BALBcJ_G0021076
 protein coding gene Chr14:23615944-23629832 (-)
C3H/HeJ MGP_C3HHeJ_G0020859
 protein coding gene Chr14:24484621-24500041 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021508
 protein coding gene Chr14:25381485-25395017 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019071
 protein coding gene Chr14:23556296-23570202 (-)
CAST/EiJ MGP_CASTEiJ_G0020384
 protein coding gene Chr14:24249041-24264274 (-)
CBA/J MGP_CBAJ_G0020826
 protein coding gene Chr14:26353961-26367483 (-)
DBA/2J MGP_DBA2J_G0020948
 protein coding gene Chr14:23521357-23535140 (-)
FVB/NJ MGP_FVBNJ_G0020932
 protein coding gene Chr14:23483778-23497456 (-)
LP/J MGP_LPJ_G0021017
 protein coding gene Chr14:24738822-24755441 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020958
 protein coding gene Chr14:25617796-25632639 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021541
 protein coding gene Chr14:24376556-24389898 (-)
PWK/PhJ MGP_PWKPhJ_G0020132
 protein coding gene Chr14:22979208-22993615 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019956
 protein coding gene Chr14:23973698-23988598 (-)
WSB/EiJ MGP_WSBEiJ_G0020439
 protein coding gene Chr14:24439187-24452686 (-)



Homology
more
  • Human Ortholog
    PHF7, PHD finger protein 7
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PHF7, PHD finger protein 7
  • Synonyms
    HSPC045, HSPC226, NYD-SP6
  • Links
    NCBI Gene ID: 51533
    neXtProt AC: NX_Q9BWX1
    UniProt: Q9BWX1

  • Chr Location
    3p21.1; chr3:52410660-52423641 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 3 alleles in 3 genetic backgrounds
    6 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditionally allele activated in sperm or a enzymatic dead allele exhibit male infertility associated with oligozoospermia, asthenozoospermia, teratozoospermia, and defective histone to protamine exchange during spermiogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    61
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021902 Ensembl Gene Model | MGI Sequence Detail 13629 C57BL/6J ±  kb
    transcript ENSMUST00000022459 Ensembl | MGI Sequence Detail 2084 Not Applicable  
    polypeptide ENSMUSP00000022459 Ensembl | MGI Sequence Detail 307 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 61
      cDNA 61

      Microarray probesets 12
    Other
    Accession IDs
    less
    MGI:1916609, MGI:2145634, MGI:2145840
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 9
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory