Serpinb12 MGI Mouse Gene Detail - MGI:1919119 - serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 12

Symbol

Serpinb12
Name

serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 12
Synonyms

2300003F07Rik, 4833409F13Rik

Feature Type

protein coding gene
IDs

MGI:1919119
NCBI Gene: 71869
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr1:106862179-106884810 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 50.34 cM, cytoband D
Mapping Data

3 experiments

SNPs within 2kb

863 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919119	protein coding gene	Chr1:106862179-106884810 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016375	protein coding gene	Chr1:109126079-109148694 (+)
A/J	MGP_AJ_G0016359	protein coding gene	Chr1:105292201-105314839 (+)
AKR/J	MGP_AKRJ_G0016319	protein coding gene	Chr1:108176392-108200056 (+)
BALB/cJ	MGP_BALBcJ_G0016315	protein coding gene	Chr1:105385207-105407760 (+)
C3H/HeJ	MGP_C3HHeJ_G0016142	protein coding gene	Chr1:108624605-108647957 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016774	protein coding gene	Chr1:113272789-113295401 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014492	protein coding gene	Chr1:99588264-99612308 (+)
CAST/EiJ	MGP_CASTEiJ_G0015724	protein coding gene	Chr1:107539804-107564449 (+)
CBA/J	MGP_CBAJ_G0016115	protein coding gene	Chr1:117141618-117168004 (+)
DBA/2J	MGP_DBA2J_G0016220	protein coding gene	Chr1:104358993-104381375 (+)
FVB/NJ	MGP_FVBNJ_G0016221	protein coding gene	Chr1:103302847-103325250 (+)
LP/J	MGP_LPJ_G0016294	protein coding gene	Chr1:110357269-110381551 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016247	protein coding gene	Chr1:121546912-121570512 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016813	protein coding gene	Chr1:108261744-108285651 (+)
PWK/PhJ	MGP_PWKPhJ_G0015512	protein coding gene	Chr1:103383278-103407293 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015297	protein coding gene	Chr1:106916095-106939556 (+)
WSB/EiJ	MGP_WSBEiJ_G0015787	protein coding gene	Chr1:108088379-108112276 (+)

Human Ortholog

SERPINB12, serpin family B member 12

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SERPINB12, serpin family B member 12
Synonyms

YUKOPIN
Links

HGNC:14220

NCBI Gene ID: 89777

neXtProt AC: NX_Q96P63

UniProt: Q96P63
Chr Location

18q21.33; chr18:63519110-63569329 (+) GRCh38

MGI Vertebrate Homology

Serpinb12 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: SERPINB12
Gene Tree

Serpinb12

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

2
Radiation induced

1
Targeted

2
Genomic Mutations

3 involving Serpinb12
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

9
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

715
Tissues

9
cDNA Data

10
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

37
RefSeq

4
UniProt

2
CCDS

CCDS15212.1

Ensembl

ENSMUSG00000059956 (Evidence)
NCBI Gene

71869

			Length	Strain/Species	Flank
genomic	71869	NCBI Gene Model \| MGI Sequence Detail	22632	C57BL/6J	± kb
transcript	NM_027971	RefSeq \| MGI Sequence Detail	1689	C57BL/6
polypeptide	Q9D7P9	UniProt \| EBI \| MGI Sequence Detail	423	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014692 serpin B12

(term hierarchy)
InterPro Domains

IPR023795 Serpin, conserved site

IPR023796 Serpin domain

IPR000215 Serpin family

IPR036186 Serpin superfamily

IPR042178 Serpin superfamily, domain 1

IPR042185 Serpin superfamily, domain 2

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All nucleic 14

Genomic 4

cDNA 10

Microarray probesets 4

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MGI:1921151

Summaries

All 37

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 10
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Serpinb12:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8322	Chr1:106862171-106862194 (+)	4 bp
Tssr8323	Chr1:106862210-106862224 (+)	38 bp
Tssr8324	Chr1:106862232-106862254 (+)	64 bp
Tssr8325	Chr1:106862260-106862270 (+)	86 bp
Tssr8326	Chr1:106866683-106866688 (+)	4,507 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24