Noxo1 MGI Mouse Gene Detail - MGI:1919143 - NADPH oxidase organizer 1

Symbol

Noxo1
Name

NADPH oxidase organizer 1
Synonyms

2310034C04Rik

Feature Type

protein coding gene
IDs

MGI:1919143
NCBI Gene: 71893
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr17:24915208-24919503 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 12.49 cM, cytoband A3.3
Mapping Data

4 experiments

SNPs within 2kb

156 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919143	protein coding gene	Chr17:24915208-24919504 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023315	protein coding gene	Chr17:23706985-23711286 (+)
A/J	MGP_AJ_G0023275	protein coding gene	Chr17:23060000-23064301 (+)
AKR/J	MGP_AKRJ_G0023242	protein coding gene	Chr17:23139473-23143782 (+)
BALB/cJ	MGP_BALBcJ_G0023280	protein coding gene	Chr17:23246288-23250592 (+)
C3H/HeJ	MGP_C3HHeJ_G0023040	protein coding gene	Chr17:23500297-23504601 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023723	protein coding gene	Chr17:24758283-24762578 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021198	protein coding gene	Chr17:20531435-20535651 (+)
CAST/EiJ	MGP_CASTEiJ_G0022542	protein coding gene	Chr17:23352218-23356534 (+)
CBA/J	MGP_CBAJ_G0023016	protein coding gene	Chr17:25606455-25610759 (+)
DBA/2J	MGP_DBA2J_G0023145	protein coding gene	Chr17:22653148-22657449 (+)
FVB/NJ	MGP_FVBNJ_G0023115	protein coding gene	Chr17:22370562-22374863 (+)
LP/J	MGP_LPJ_G0023222	protein coding gene	Chr17:24013425-24017726 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023134	protein coding gene	Chr17:25304432-25308733 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023761	protein coding gene	Chr17:23422036-23426337 (+)
PWK/PhJ	MGP_PWKPhJ_G0022291	protein coding gene	Chr17:21395365-21399665 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022109	protein coding gene	Chr17:21462013-21466293 (+)
WSB/EiJ	MGP_WSBEiJ_G0022605	protein coding gene	Chr17:23489529-23494956 (+)

Human Ortholog

NOXO1, NADPH oxidase organizer 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NOXO1, NADPH oxidase organizer 1
Synonyms

P41NOX, P41NOXA, P41NOXB, P41NOXC, SH3PXD5, SNX28
Links

HGNC:19404

NCBI Gene ID: 124056

neXtProt AC: NX_Q8NFA2

UniProt: Q8NFA2
Chr Location

16p13.3; chr16:1978917-1984192 (-) GRCh38

MGI Vertebrate Homology

Noxo1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: NOXO1
Gene Tree

Noxo1

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
1 images
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Spontaneous

1
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mutations at this locus affect the inner ear and result in vestibular related movement anomalies.

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All GO Annotations

14
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

718
Tissues

3
cDNA Data

40
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase noxo1, noxo1.2

ZFIN noxo1a, noxo1b

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All Sequences

55
RefSeq

10
UniProt

3
CCDS

CCDS50018.1

Ensembl

ENSMUSG00000019320 (Evidence)
NCBI Gene

71893

			Length	Strain/Species	Flank
genomic	ENSMUSG00000019320	Ensembl Gene Model \| MGI Sequence Detail	4296	C57BL/6J	± kb
transcript	ENSMUST00000019464	Ensembl \| MGI Sequence Detail	2238	Not Applicable
polypeptide	ENSMUSP00000019464	Ensembl \| MGI Sequence Detail	349	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000011343 NADPH oxidase organizer 1

(term hierarchy)
InterPro Domains

IPR051228 NADPH Oxidase and PX Domain-Containing

IPR035758 NADPH oxidase organiser 1, second SH3 domain

IPR001683 Phox homology

IPR036871 PX domain superfamily

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily

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All nucleic 40

cDNA 40

Microarray probesets 3

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MGI:2675599

Summaries

All 38

Developmental Gene Expression 2

Gene Ontology 7

Phenotypes 7
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:347791 Seimetz M, et al., NADPH oxidase subunit NOXO1 is a target for emphysema treatment in COPD. Nat Metab. 2020 Jun;2(6):532-546

TSS for Noxo1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr143060	Chr17:24915250-24915294 (+)	64 bp
Tssr143061	Chr17:24915634-24915638 (+)	428 bp
Tssr143062	Chr17:24917194-24917226 (+)	2,002 bp
Tssr143063	Chr17:24917268-24917319 (+)	2,086 bp
Tssr143064	Chr17:24917323-24917345 (+)	2,126 bp
Tssr5035	Chr17:24918773-24918781 (+)	3,569 bp
Tssr143065	Chr17:24918877-24918879 (+)	3,670 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24