Lypd6b MGI Mouse Gene Detail - MGI:1919147 - LY6/PLAUR domain containing 6B

Symbol

Lypd6b
Name

LY6/PLAUR domain containing 6B
Synonyms

2310010M24Rik

Feature Type

protein coding gene
IDs

MGI:1919147
NCBI Gene: 71897
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr2:49677700-49838861 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 28.74 cM
Mapping Data

2 experiments

SNPs within 2kb

5022 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919147	protein coding gene	Chr2:49677380-49838861 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025724	protein coding gene	Chr2:48983711-49154210 (+)
A/J	MGP_AJ_G0025700	protein coding gene	Chr2:47121795-47285861 (+)
AKR/J	MGP_AKRJ_G0025670	protein coding gene	Chr2:48471711-48640055 (+)
BALB/cJ	MGP_BALBcJ_G0025695	protein coding gene	Chr2:47239677-47404293 (+)
C3H/HeJ	MGP_C3HHeJ_G0025456	protein coding gene	Chr2:48453991-48625851 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026141	protein coding gene	Chr2:50457616-50629755 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023547	protein coding gene	Chr2:45161633-45320723 (+)
CAST/EiJ	MGP_CASTEiJ_G0024921	protein coding gene	Chr2:48520399-48699344 (+)
CBA/J	MGP_CBAJ_G0025436	protein coding gene	Chr2:52337160-52512432 (+)
DBA/2J	MGP_DBA2J_G0025567	protein coding gene	Chr2:46743825-46906851 (+)
FVB/NJ	MGP_FVBNJ_G0025529	protein coding gene	Chr2:46474989-46637696 (+)
LP/J	MGP_LPJ_G0025655	protein coding gene	Chr2:48910494-49076916 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025560	protein coding gene	Chr2:53403347-53576944 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026199	protein coding gene	Chr2:48371913-48545183 (+)
PWK/PhJ	MGP_PWKPhJ_G0024662	protein coding gene	Chr2:46629885-46795749 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024468	protein coding gene	Chr2:48549204-48720814 (+)
WSB/EiJ	MGP_WSBEiJ_G0024988	protein coding gene	Chr2:48633272-48802917 (+)

Human Ortholog

LYPD6B, LY6/PLAUR domain containing 6B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LYPD6B, LY6/PLAUR domain containing 6B
Synonyms

CT116, LYPD7
Links

HGNC:27018

NCBI Gene ID: 130576

neXtProt AC: NX_Q8NI32

UniProt: Q8NI32
Chr Location

2q23.2; chr2:149038107-149215262 (+) GRCh38

MGI Vertebrate Homology

Lypd6b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LYPD6B
Gene Tree

Lypd6b

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Targeted

4
Genomic Mutations

1 involving Lypd6b
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

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All GO Annotations

5
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

775
Tissues

25
cDNA Data

15
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lypd6b

ZFIN lypd6b

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All Sequences

59
RefSeq

30
UniProt

1
CCDS

CCDS16025.1

Ensembl

ENSMUSG00000026765 (Evidence)
NCBI Gene

71897

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026765	Ensembl Gene Model \| MGI Sequence Detail	161162	C57BL/6J	± kb
transcript	ENSMUST00000028103	Ensembl \| MGI Sequence Detail	2286	Not Applicable
polypeptide	ENSMUSP00000028103	Ensembl \| MGI Sequence Detail	172	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000031499 Ly6/PLAUR domain-containing protein 6B

(term hierarchy)
InterPro Domains

IPR039457 Ly6/PLAUR domain-containing protein 6-like

IPR045860 Snake toxin-like superfamily
GlyGen

Q9D7F2 1 site, 1 N-linked glycan (1 site)

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All nucleic 15

cDNA 15

Microarray probesets 3

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MGI:2139280

Summaries

All 35

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Lypd6b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr490	Chr2:49677678-49677687 (+)	-17 bp
Tssr17686	Chr2:49677687-49677707 (+)	-3 bp
Tssr17687	Chr2:49677723-49677737 (+)	30 bp
Tssr17688	Chr2:49685675-49685700 (+)	7,988 bp
Tssr17689	Chr2:49701699-49701713 (+)	24,006 bp
Tssr17690	Chr2:49736329-49736368 (+)	58,649 bp
Tssr17691	Chr2:49780369-49780373 (+)	102,671 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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