Cipc MGI Mouse Gene Detail - MGI:1919185 - CLOCK interacting protein, circadian

Symbol

Cipc
Name

CLOCK interacting protein, circadian
Synonyms

2310044G17Rik, mKIAA1737

Feature Type

protein coding gene
IDs

MGI:1919185
NCBI Gene: 217732
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr12:86993817-87012136 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 41.13 cM
Mapping Data

2 experiments

SNPs within 2kb

516 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919185	protein coding gene	Chr12:86993817-87012138 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019974	protein coding gene	Chr12:87824666-87843910 (+)
A/J	MGP_AJ_G0019932	protein coding gene	Chr12:84490954-84509273 (+)
AKR/J	MGP_AKRJ_G0019907	protein coding gene	Chr12:86779145-86797459 (+)
BALB/cJ	MGP_BALBcJ_G0019911	protein coding gene	Chr12:84825292-84843228 (+)
C3H/HeJ	MGP_C3HHeJ_G0019717	protein coding gene	Chr12:87268556-87287105 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020363	protein coding gene	Chr12:90363264-90381579 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017981	protein coding gene	Chr12:81373240-81392988 (+)
CAST/EiJ	MGP_CASTEiJ_G0019267	protein coding gene	Chr12:82272570-82293358 (+)
CBA/J	MGP_CBAJ_G0019689	protein coding gene	Chr12:93834238-93855579 (+)
DBA/2J	MGP_DBA2J_G0019802	protein coding gene	Chr12:83980373-83998641 (+)
FVB/NJ	MGP_FVBNJ_G0019789	protein coding gene	Chr12:82973920-82992241 (+)
LP/J	MGP_LPJ_G0019876	protein coding gene	Chr12:87705904-87724126 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019828	protein coding gene	Chr12:96588715-96609018 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020395	protein coding gene	Chr12:86409271-86429090 (+)
PWK/PhJ	MGP_PWKPhJ_G0019031	protein coding gene	Chr12:78534151-78552873 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018826	protein coding gene	Chr12:80900770-80920455 (+)
WSB/EiJ	MGP_WSBEiJ_G0019320	protein coding gene	Chr12:87150054-87169684 (+)

Human Ortholog

CIPC, CLOCK interacting pacemaker

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CIPC, CLOCK interacting pacemaker
Synonyms

KIAA1737
Links

HGNC:20365

NCBI Gene ID: 85457

neXtProt AC: NX_Q9C0C6

UniProt: Q9C0C6
Chr Location

14q24.3; chr14:77098126-77117287 (+) GRCh38

MGI Vertebrate Homology

Cipc stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CIPC
Gene Tree

Cipc

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
11 phenotype references

All Mutations and Alleles

20
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

13
Targeted

2
Genomic Mutations

1 involving Cipc
Find Mice (IMSR)

19 strains or lines available

Mice homozygous for a knock-out allele exhibit normal circadian rhythms and behaviors.

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All GO Annotations

13
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

128

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cipc

ZFIN cipca

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All Sequences

94
RefSeq

27
UniProt

7
CCDS

CCDS56849.1

Ensembl

ENSMUSG00000034157 (Evidence)
NCBI Gene

217732

			Length	Strain/Species	Flank
genomic	ENSMUSG00000034157	Ensembl Gene Model \| MGI Sequence Detail	18320	C57BL/6J	± kb
transcript	ENSMUST00000187814	Ensembl \| MGI Sequence Detail	4098	Not Applicable
polypeptide	ENSMUSP00000141049	Ensembl \| MGI Sequence Detail	432	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000060063 CLOCK-interacting pacemaker

(term hierarchy)
PDB

5VJI, 5VJX
InterPro Domains

IPR031602 Clock-interacting pacemaker

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All nucleic 128

cDNA 128

Microarray probesets 6

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MGI:2144895, MGI:2144908

Summaries

All 37

Gene Ontology 6

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:328244 Zheng J, et al., Satellite cell-specific deletion of Cipc alleviates myopathy in mdx mice. Cell Rep. 2022 Jun 14;39(11):110939

TSS for Cipc:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114489	Chr12:86993295-86993306 (+)	-516 bp
Tssr114490	Chr12:86993805-86993829 (+)	0 bp
Tssr114491	Chr12:86994143-86994204 (+)	357 bp
Tssr114492	Chr12:86994205-86994255 (+)	413 bp
Tssr114493	Chr12:86995654-86995657 (+)	1,839 bp
Tssr114494	Chr12:86996496-86996516 (+)	2,689 bp
Tssr114495	Chr12:86999274-86999283 (+)	5,462 bp
Tssr114496	Chr12:86999367-86999388 (+)	5,561 bp
Tssr114497	Chr12:86999510-86999518 (+)	5,697 bp
Tssr114498	Chr12:87007137-87007165 (+)	13,334 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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