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Cars2 Gene Detail
Summary
  • Symbol
    Cars2
  • Name
    cysteinyl-tRNA synthetase 2, mitochondrial
  • Synonyms
    2310051N18Rik, 2410044A07Rik, D530030H10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919191
    NCBI Gene: 71941
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:11564017-11600781 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 5.73 cM, cytoband A2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1229 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919191
 protein coding gene Chr8:11563977-11600783 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033355
 protein coding gene Chr8:8725828-8765097 (-)
A/J MGP_AJ_G0033335
 protein coding gene Chr8:8431611-8470544 (-)
AKR/J MGP_AKRJ_G0033266
 protein coding gene Chr8:8682690-8722693 (-)
BALB/cJ MGP_BALBcJ_G0033336
 protein coding gene Chr8:8577432-8614302 (-)
C3H/HeJ MGP_C3HHeJ_G0033049
 protein coding gene Chr8:8846855-8891201 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033848
 protein coding gene Chr8:9076516-9115006 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030818
 protein coding gene Chr8:7961216-8000246 (-)
CAST/EiJ MGP_CASTEiJ_G0032371
 protein coding gene Chr8:8587216-8631633 (-)
CBA/J MGP_CBAJ_G0033022
 protein coding gene Chr8:9453505-9508915 (-)
DBA/2J MGP_DBA2J_G0033175
 protein coding gene Chr8:8416083-8452431 (-)
FVB/NJ MGP_FVBNJ_G0033124
 protein coding gene Chr8:8381742-8419963 (-)
LP/J MGP_LPJ_G0033269
 protein coding gene Chr8:8647954-8690616 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033158
 protein coding gene Chr8:9766917-9809825 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033865
 protein coding gene Chr8:8695497-8739049 (-)
PWK/PhJ MGP_PWKPhJ_G0032084
 protein coding gene Chr8:8403904-8444191 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031926
 protein coding gene Chr8:8610967-8654103 (-)
WSB/EiJ MGP_WSBEiJ_G0032487
 protein coding gene Chr8:8733358-8779328 (-)



Homology
more
  • Human Ortholog
    CARS2, cysteinyl-tRNA synthetase 2, mitochondrial
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CARS2, cysteinyl-tRNA synthetase 2, mitochondrial
  • Synonyms
    COXPD27, cysRS
  • Links
    NCBI Gene ID: 79587
    neXtProt AC: NX_Q9HA77
    UniProt: Q9HA77

  • Chr Location
    13q34; chr13:110641410-110713603 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CARS2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 4 alleles in 3 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced allele develop induced hyperactivity followed by head bobbing and tremors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    3
  • cDNA Data
    28
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 71941 NCBI Gene Model | MGI Sequence Detail 36765 C57BL/6J ±  kb
    transcript NM_024248 RefSeq | MGI Sequence Detail 1867 C57BL/6  
    polypeptide Q8BYM8 UniProt | EBI | MGI Sequence Detail 551 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • Protein Ontology
      PR:000029774 probable cysteine--tRNA ligase, mitochondrial
      (term hierarchy)
    • EC
      6.1.1.16
    • InterPro Domains
      IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding
      IPR015803 Cysteine-tRNA ligase
      IPR024909 Cysteinyl-tRNA synthetase/mycothiol ligase
      IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
      IPR032678 tRNA synthetases class I, catalytic domain
    • GlyGen
      Q8BYM8 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 29
      cDNA 28
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1917241, MGI:1925966
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 1
      Gene Ontology 7
      Phenotypes 9
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory