Ints11 MGI Mouse Gene Detail - MGI:1919207 - integrator complex subunit 11

Symbol

Ints11
Name

integrator complex subunit 11
Synonyms

2410006F12Rik, Cpsf3l

Feature Type

protein coding gene
IDs

MGI:1919207
NCBI Gene: 71957
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr4:155954006-155973561 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 87.66 cM
Mapping Data

3 experiments

SNPs within 2kb

796 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919207	protein coding gene	Chr4:155954003-155973561 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029236	protein coding gene	Chr4:160240006-160261890 (+)
A/J	MGP_AJ_G0029201	protein coding gene	Chr4:153487882-153508318 (+)
AKR/J	MGP_AKRJ_G0029149	protein coding gene	Chr4:157666651-157686329 (+)
BALB/cJ	MGP_BALBcJ_G0029217	protein coding gene	Chr4:153961574-153981439 (+)
C3H/HeJ	MGP_C3HHeJ_G0028938	protein coding gene	Chr4:158209282-158229043 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029666	protein coding gene	Chr4:165916948-165939423 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026910	protein coding gene	Chr4:145776364-145795322 (+)
CAST/EiJ	MGP_CASTEiJ_G0028350	protein coding gene	Chr4:155680788-155699892 (+)
CBA/J	MGP_CBAJ_G0028900	protein coding gene	Chr4:170931765-170956072 (+)
DBA/2J	MGP_DBA2J_G0029049	protein coding gene	Chr4:153508729-153529511 (+)
FVB/NJ	MGP_FVBNJ_G0029012	protein coding gene	Chr4:152758053-152780137 (+)
LP/J	MGP_LPJ_G0029139	protein coding gene	Chr4:160167453-160191666 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029039	protein coding gene	Chr4:173745470-173765497 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029698	protein coding gene	Chr4:158292705-158318965 (+)
PWK/PhJ	MGP_PWKPhJ_G0028071	protein coding gene	Chr4:149652255-149672464 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027905	protein coding gene	Chr4:152551900-152574785 (+)
WSB/EiJ	MGP_WSBEiJ_G0028430	protein coding gene	Chr4:158466726-158489220 (+)

Human Ortholog

INTS11, integrator complex subunit 11

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

INTS11, integrator complex subunit 11
Synonyms

CPSF3L, CPSF73L, INT11, NEDMLOB, PSF3L, RC-68, RC68
Links

HGNC:26052

NCBI Gene ID: 54973

neXtProt AC: NX_Q5TA45

UniProt: Q5TA45
Chr Location

1p36.33; chr1:1311585-1324687 (-) GRCh38

MGI Vertebrate Homology

Ints11 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: INTS11
Gene Tree

Ints11

Diseases

1 with human INTS11 associations

				Human Disease	Mouse Models
				neurodevelopmental disorder with motor and language delay, ocular defects, and brain abnormalities IDs neurodevelopmental disorder with motor and language delay, ocular defects, and brain abnormalities DOID:0081387 OMIM:620428

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

3
Gene trapped

2
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

37 strains or lines available

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All GO Annotations

17
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

89
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ints11

ZFIN ints11

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All Sequences

62
RefSeq

10
UniProt

3
CCDS

CCDS19048.1

Ensembl

ENSMUSG00000029034 (Evidence)
NCBI Gene

71957

			Length	Strain/Species	Flank
genomic	71957	NCBI Gene Model \| MGI Sequence Detail	19556	C57BL/6J	± kb
transcript	NM_028020	RefSeq \| MGI Sequence Detail	2350	ZRU/MplStud
polypeptide	Q9CWS4	UniProt \| EBI \| MGI Sequence Detail	600	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000005831 integrator complex subunit 11

(term hierarchy)
EC

3.1.27.-
InterPro Domains

IPR022712 Beta-Casp domain

IPR048662 Integrator complex subunit 11, C-terminal domain

IPR041897 Integrator complex subunit 11, MBL-fold

IPR001279 Metallo-beta-lactamase

IPR036866 Ribonuclease Z/Hydroxyacylglutathione hydrolase-like

IPR050698 RNA Processing Metallo-Beta-Lactamase Domain-Containing Protein

IPR011108 Zn-dependent metallo-hydrolase, RNA specificity domain

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All nucleic 91

Genomic 1

cDNA 90

Microarray probesets 2

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MGI:2140491

Summaries

All 36

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 10
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ints11:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr40737	Chr4:155953997-155954080 (+)	33 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24