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Myh14 Gene Detail
Summary
  • Symbol
    Myh14
  • Name
    myosin, heavy polypeptide 14
  • Synonyms
    2400004E04Rik, NMHC II-C
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919210
    NCBI Gene: 71960
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:44255227-44320267 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 28.85 cM, cytoband B2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2008 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919210
 protein coding gene Chr7:44255227-44320296 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032172
 protein coding gene Chr7:44786682-44852156 (-)
A/J MGP_AJ_G0032151
 protein coding gene Chr7:43965677-44024789 (-)
AKR/J MGP_AKRJ_G0032087
 protein coding gene Chr7:45172568-45236075 (-)
BALB/cJ MGP_BALBcJ_G0032163
 protein coding gene Chr7:43962948-44022783 (-)
C3H/HeJ MGP_C3HHeJ_G0031879
 protein coding gene Chr7:45664102-45726255 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032655
 protein coding gene Chr7:47044641-47110465 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029669
 protein coding gene Chr7:46547241-46608780 (-)
CAST/EiJ MGP_CASTEiJ_G0031207
 protein coding gene Chr7:37041901-37108261 (-)
CBA/J MGP_CBAJ_G0031843
 protein coding gene Chr7:48595807-48661987 (-)
DBA/2J MGP_DBA2J_G0032001
 protein coding gene Chr7:43637421-43697399 (-)
FVB/NJ MGP_FVBNJ_G0031952
 protein coding gene Chr7:43385378-43451785 (-)
LP/J MGP_LPJ_G0032079
 protein coding gene Chr7:45470159-45532635 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031989
 protein coding gene Chr7:47339153-47404313 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032671
 protein coding gene Chr7:44392538-44455104 (-)
PWK/PhJ MGP_PWKPhJ_G0030930
 protein coding gene Chr7:36991060-37052571 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030767
 protein coding gene Chr7:32398018-32459184 (-)
WSB/EiJ MGP_WSBEiJ_G0031324
 protein coding gene Chr7:44858077-44925103 (-)



Homology
more
  • Human Ortholog
    MYH14, myosin heavy chain 14
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MYH14, myosin heavy chain 14
  • Synonyms
    DFNA4, DFNA4A, FP17425, MHC16, MYH17, myosin, NMHC II-C, NMHC-II-C, PNMHH
  • Links
    NCBI Gene ID: 79784
    neXtProt AC: NX_Q7Z406
    UniProt: Q7Z406

  • Chr Location
    19q13.33; chr19:50188186-50310542 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human MYH14 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are healthy and survive to adulthood with no apparent defects. About 30% of knock-in mice either heterozygous or homozygous for a single amino acid mutation exhibit increased lymphoma incidence.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    831
  • Tissues
    42
  • cDNA Data
    41
  • Literature Summary
    21
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030739 Ensembl Gene Model | MGI Sequence Detail 65041 C57BL/6J ±  kb
transcript ENSMUST00000207775 Ensembl | MGI Sequence Detail 6499 Not Applicable  
polypeptide ENSMUSP00000147115 Ensembl | MGI Sequence Detail 2033 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 44
    cDNA 41
    Primer pair 3

    Microarray probesets 3
References
more
  • Summaries
    All 66
    Developmental Gene Expression 21
    Gene Ontology 11
    Phenotypes 16
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:354663 Silverman JB, et al., Organization of a cytoskeletal superstructure in the apical domain of intestinal tuft cells. J Cell Biol. 2024;223(12):e202404070
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory