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Atad3a Gene Detail
Summary
  • Symbol
    Atad3a
  • Name
    ATPase family, AAA domain containing 3A
  • Synonyms
    2400004H09Rik, Tob3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919214
    NCBI Gene: 108888
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:155825098-155845550 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 87.20 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    856 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919214
 protein coding gene Chr4:155825097-155845579 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029225
 protein coding gene Chr4:160095683-160119092 (-)
A/J MGP_AJ_G0029190
 protein coding gene Chr4:153358996-153379220 (-)
AKR/J MGP_AKRJ_G0029138
 protein coding gene Chr4:157525097-157547040 (-)
BALB/cJ MGP_BALBcJ_G0029206
 protein coding gene Chr4:153830986-153852095 (-)
C3H/HeJ MGP_C3HHeJ_G0028927
 protein coding gene Chr4:158073370-158094462 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029655
 protein coding gene Chr4:165778706-165800898 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026900
 protein coding gene Chr4:145645411-145666105 (-)
CAST/EiJ MGP_CASTEiJ_G0028339
 protein coding gene Chr4:155532697-155555071 (-)
CBA/J MGP_CBAJ_G0028889
 protein coding gene Chr4:170785664-170810340 (-)
DBA/2J MGP_DBA2J_G0029038
 protein coding gene Chr4:153378922-153399759 (-)
FVB/NJ MGP_FVBNJ_G0029001
 protein coding gene Chr4:152624687-152645272 (-)
LP/J MGP_LPJ_G0029128
 protein coding gene Chr4:160008682-160032687 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029028
 protein coding gene Chr4:173595491-173618509 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029687
 protein coding gene Chr4:158158068-158179735 (-)
PWK/PhJ MGP_PWKPhJ_G0028060
 protein coding gene Chr4:149517813-149538949 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027894
 protein coding gene Chr4:152410295-152431067 (-)
WSB/EiJ MGP_WSBEiJ_G0028419
 protein coding gene Chr4:158323915-158345613 (-)



Homology
more
  • Human Ortholog
    ATAD3A, ATPase family AAA domain containing 3A
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATAD3A, ATPase family AAA domain containing 3A
  • Synonyms
    HAYOS, PHRINL
  • Links
    NCBI Gene ID: 55210
    neXtProt AC: NX_Q9NVI7
    UniProt: Q9NVI7

  • Chr Location
    1p36.33; chr1:1512162-1534685 (+)  GRCh38
  • Human Ortholog
    ATAD3B, ATPase family AAA domain containing 3B
  • Synonyms
    AAA-TOB3, TOB3
  • Links
    NCBI Gene ID: 83858
    neXtProt AC: NX_Q5T9A4
    UniProt: Q5T9A4

  • Chr Location
    1p36.33; chr1:1471765-1509466 (+)  GRCh38
  • Human Ortholog
    ATAD3C, ATPase family AAA domain containing 3C
  • Links
    NCBI Gene ID: 219293
    neXtProt AC: NX_Q5T2N8
    UniProt: Q5T2N8

  • Chr Location
    1p36.33; chr1:1449689-1470163 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human ATAD3A associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 3 alleles in 3 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele die around E7.5 exhibiting growth retardation, failure to gastrulate, and impaired development of the trophoblast lineage immediately after implantation. Conditional homozygous KO in skeletal muscle causes progressive myopathy as a result of abnormal mitochondrial morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    736
  • Tissues
    17
  • cDNA Data
    116
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029036 Ensembl Gene Model | MGI Sequence Detail 20453 C57BL/6J ±  kb
    transcript ENSMUST00000030903 Ensembl | MGI Sequence Detail 2413 Not Applicable  
    polypeptide ENSMUSP00000030903 Ensembl | MGI Sequence Detail 591 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000030707 ATPase family AAA domain-containing protein 3A
      (term hierarchy)
    • EC
      3.6.1.-
    • InterPro Domains
      IPR003593 AAA+ ATPase domain
      IPR003959 ATPase, AAA-type, core
      IPR039188 ATPase family AAA domain-containing protein 3
      IPR021911 ATPase family AAA domain-containing protein 3, N-terminal
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    • GlyGen
      Q925I1 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 118
      cDNA 116
      Primer pair 2

      Microarray probesets 6
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 3
      Gene Ontology 10
      Phenotypes 13
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory