Tmco6 MGI Mouse Gene Detail - MGI:1919233 - transmembrane and coiled-coil domains 6

Symbol

Tmco6
Name

transmembrane and coiled-coil domains 6
Synonyms

2410015B03Rik

Feature Type

protein coding gene
IDs

MGI:1919233
NCBI Gene: 71983
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr18:36868092-36875450 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 19.46 cM, cytoband B3
Mapping Data

2 experiments

SNPs within 2kb

327 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919233	protein coding gene	Chr18:36868072-36875453 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024286	protein coding gene	Chr18:35147304-35155423 (+)
A/J	MGP_AJ_G0024252	protein coding gene	Chr18:33908504-33916454 (+)
AKR/J	MGP_AKRJ_G0024220	protein coding gene	Chr18:34864291-34871504 (+)
BALB/cJ	MGP_BALBcJ_G0024252	protein coding gene	Chr18:33958368-33965585 (+)
C3H/HeJ	MGP_C3HHeJ_G0024019	protein coding gene	Chr18:34926479-34935435 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024693	protein coding gene	Chr18:36381930-36390580 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022133	protein coding gene	Chr18:34002576-34008885 (+)
CAST/EiJ	MGP_CASTEiJ_G0023494	protein coding gene	Chr18:34943125-34950217 (+)
CBA/J	MGP_CBAJ_G0023987	protein coding gene	Chr18:37459903-37469707 (+)
DBA/2J	MGP_DBA2J_G0024119	protein coding gene	Chr18:33525736-33533535 (+)
FVB/NJ	MGP_FVBNJ_G0024086	protein coding gene	Chr18:33234068-33243216 (+)
LP/J	MGP_LPJ_G0024201	protein coding gene	Chr18:35181146-35189688 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024114	protein coding gene	Chr18:38675570-38682797 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024742	protein coding gene	Chr18:34733943-34741174 (+)
PWK/PhJ	MGP_PWKPhJ_G0023238	protein coding gene	Chr18:33787199-33794380 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023045	protein coding gene	Chr18:34986543-34993643 (+)
WSB/EiJ	MGP_WSBEiJ_G0023557	protein coding gene	Chr18:34654348-34661607 (+)

Human Ortholog

TMCO6, transmembrane and coiled-coil domains 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMCO6, transmembrane and coiled-coil domains 6
Synonyms

PRO1580
Links

HGNC:28814

NCBI Gene ID: 55374

neXtProt AC: NX_Q96DC7

UniProt: Q96DC7
Chr Location

5q31.3; chr5:140596530-140647732 (+) GRCh38

MGI Vertebrate Homology

Tmco6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TMCO6
Gene Tree

Tmco6

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Phenotype Summary

10 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Gene trapped

4
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

3
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

760
Tissues

47
cDNA Data

17
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tmco6

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All Sequences

44
RefSeq

6
UniProt

2
CCDS

CCDS37772.1

Ensembl

ENSMUSG00000006850 (Evidence)
NCBI Gene

71983

			Length	Strain/Species	Flank
genomic	ENSMUSG00000006850	Ensembl Gene Model \| MGI Sequence Detail	7359	C57BL/6J	± kb
transcript	ENSMUST00000007046	Ensembl \| MGI Sequence Detail	1823	Not Applicable
polypeptide	ENSMUSP00000007046	Ensembl \| MGI Sequence Detail	494	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000032691 transmembrane and coiled-coil domain-containing protein 6

(term hierarchy)
InterPro Domains

IPR000225 Armadillo

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR002652 Importin-alpha, importin-beta-binding domain

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All nucleic 17

cDNA 17

Microarray probesets 3

Summaries

All 30

Developmental Gene Expression 1

Gene Ontology 2

Phenotypes 7
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:359019 Song M, et al., DNA of Neutrophil Extracellular Traps Binds TMCO6 to Impair CD8+ T-cell Immunity in Hepatocellular Carcinoma. Cancer Res. 2024 May 15;84(10):1613-1629

TSS for Tmco6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr150662	Chr18:36868065-36868079 (+)	-20 bp
Tssr150663	Chr18:36868085-36868111 (+)	6 bp
Tssr150664	Chr18:36868170-36868230 (+)	108 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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