Ddx54 MGI Mouse Gene Detail - MGI:1919240

Symbol

Ddx54
Name

DEAD box helicase 54
Synonyms

2410015A15Rik, APR-5, DEAD (Asp-Glu-Ala-Asp) box polypeptide 54, DP97

Feature Type

protein coding gene
IDs

MGI:1919240
NCBI Gene: 71990
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr5:120751182-120766657 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 60.63 cM
Mapping Data

3 experiments

SNPs within 2kb

448 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919240	protein coding gene	Chr5:120750804-120766657 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030009	protein coding gene	Chr5:123997684-124013537 (+)
A/J	MGP_AJ_G0029973	protein coding gene	Chr5:118858422-118874257 (+)
AKR/J	MGP_AKRJ_G0029912	protein coding gene	Chr5:122696128-122711981 (+)
BALB/cJ	MGP_BALBcJ_G0029984	protein coding gene	Chr5:120275948-120291741 (+)
C3H/HeJ	MGP_C3HHeJ_G0029704	protein coding gene	Chr5:123229797-123245654 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030439	protein coding gene	Chr5:128652556-128668424 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027665	protein coding gene	Chr5:113568684-113584752 (+)
CAST/EiJ	MGP_CASTEiJ_G0029113	protein coding gene	Chr5:122357414-122374910 (+)
CBA/J	MGP_CBAJ_G0029672	protein coding gene	Chr5:133645944-133661712 (+)
DBA/2J	MGP_DBA2J_G0029822	protein coding gene	Chr5:118944459-118960310 (+)
FVB/NJ	MGP_FVBNJ_G0029778	protein coding gene	Chr5:117871158-117887174 (+)
LP/J	MGP_LPJ_G0029910	protein coding gene	Chr5:124454869-124470669 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029809	protein coding gene	Chr5:137610745-137627703 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030480	protein coding gene	Chr5:122274147-122291044 (+)
PWK/PhJ	MGP_PWKPhJ_G0028826	protein coding gene	Chr5:117705622-117721683 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028665	protein coding gene	Chr5:119936627-119954445 (+)
WSB/EiJ	MGP_WSBEiJ_G0029188	protein coding gene	Chr5:122867429-122883250 (+)

Human Ortholog

DDX54, DEAD-box helicase 54

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DDX54, DEAD-box helicase 54
Synonyms

DP97
Links

HGNC:20084

NCBI Gene ID: 79039

neXtProt AC: NX_Q8TDD1

UniProt: Q8TDD1
Chr Location

12q24.13; chr12:113157173-113185479 (-) GRCh38

MGI Vertebrate Homology

Ddx54 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DDX54
Gene Tree

Ddx54

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

7
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Ddx54
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

40 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

26
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

728
Tissues

17
cDNA Data

19
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ddx54

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All Sequences

70
RefSeq

3
UniProt

6
CCDS

CCDS39241.1

Ensembl

ENSMUSG00000029599 (Evidence)
NCBI Gene

71990

			Length	Strain/Species	Flank
genomic	71990	NCBI Gene Model \| MGI Sequence Detail	15476	C57BL/6J	± kb
transcript	NM_028041	RefSeq \| MGI Sequence Detail	3944	C57BL/6
polypeptide	Q8K4L0	UniProt \| EBI \| MGI Sequence Detail	874	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000006369 ATP-dependent RNA helicase DDX54

(term hierarchy)
EC

3.6.4.13
InterPro Domains

IPR000629 ATP-dependent RNA helicase DEAD-box, conserved site

IPR012541 DBP10, C-terminal

IPR033517 DDX54/DBP10 family, DEAD-box helicase domain

IPR050079 DEAD box RNA helicase

IPR011545 DEAD/DEAH box helicase domain

IPR001650 Helicase, C-terminal domain-like

IPR014001 Helicase superfamily 1/2, ATP-binding domain

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR014014 RNA helicase, DEAD-box type, Q motif

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All nucleic 27

Genomic 8

cDNA 19

Microarray probesets 6

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MGI:2140860

Summaries

All 46

Developmental Gene Expression 2

Gene Ontology 7

Phenotypes 14
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ddx54:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr48519	Chr5:120751157-120751196 (+)	-5 bp
Tssr48520	Chr5:120751208-120751217 (+)	31 bp
Tssr48521	Chr5:120751453-120751455 (+)	272 bp
Tssr48522	Chr5:120759376-120759383 (+)	8,198 bp
Tssr48523	Chr5:120759421-120759462 (+)	8,260 bp
Tssr48524	Chr5:120759479-120759501 (+)	8,308 bp
Tssr48525	Chr5:120759507-120759528 (+)	8,336 bp
Tssr48526	Chr5:120759666-120759681 (+)	8,492 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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