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Smg9 Gene Detail
Summary
  • Symbol
    Smg9
  • Name
    SMG9 nonsense mediated mRNA decay factor
  • Synonyms
    1500002O20Rik, N28092, smg-9 homolog, nonsense mediated mRNA decay factor (C. elegans)
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919247
    NCBI Gene: 71997
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:24099106-24122197 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 10.54 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    969 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919247
 protein coding gene Chr7:24099044-24122203 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031827
 protein coding gene Chr7:22719476-22743654 (+)
A/J MGP_AJ_G0031806
 protein coding gene Chr7:22198535-22225155 (+)
AKR/J MGP_AKRJ_G0031735
 protein coding gene Chr7:22698031-22725149 (+)
BALB/cJ MGP_BALBcJ_G0031812
 protein coding gene Chr7:22408817-22431921 (+)
C3H/HeJ MGP_C3HHeJ_G0031532
 protein coding gene Chr7:23109393-23133176 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032275
 protein coding gene Chr7:23465811-23488928 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029333
 protein coding gene Chr7:23672371-23695646 (+)
CAST/EiJ MGP_CASTEiJ_G0030873
 protein coding gene Chr7:16571955-16596540 (+)
CBA/J MGP_CBAJ_G0031497
 protein coding gene Chr7:24347434-24373100 (+)
DBA/2J MGP_DBA2J_G0031651
 protein coding gene Chr7:22115551-22138750 (+)
FVB/NJ MGP_FVBNJ_G0031604
 protein coding gene Chr7:22070814-22095184 (+)
LP/J MGP_LPJ_G0031730
 protein coding gene Chr7:23071423-23094644 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031641
 protein coding gene Chr7:24127364-24151376 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032307
 protein coding gene Chr7:22413903-22437650 (+)
PWK/PhJ MGP_PWKPhJ_G0030597
 protein coding gene Chr7:17003590-17026560 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030427
 protein coding gene Chr7:13747889-13770626 (+)
WSB/EiJ MGP_WSBEiJ_G0030976
 protein coding gene Chr7:22536220-22559242 (+)



Homology
more
  • Human Ortholog
    SMG9, SMG9 nonsense mediated mRNA decay factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SMG9, SMG9 nonsense mediated mRNA decay factor
  • Synonyms
    C19orf61, F17127_1, HBMS, NEDITPO
  • Links
    NCBI Gene ID: 56006
    neXtProt AC: NX_Q9H0W8
    UniProt: Q9H0W8

  • Chr Location
    19q13.31; chr19:43727983-43754962 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    74 phenotypes from 2 alleles in 3 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a severe hypomorphic allele exhibit edema, hemorrhage, exencephaly, preaxial polydactyly, reduced size and growth, decreased mid- and hindrain size, microphthalmia, thin myocardium and atrioventricular septal defect.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    56
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 71997 NCBI Gene Model | MGI Sequence Detail 23092 C57BL/6J ±  kb
    transcript NM_028047 RefSeq | MGI Sequence Detail 2174 C57BL/6  
    polypeptide Q9DB90 UniProt | EBI | MGI Sequence Detail 520 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000030999 nonsense-mediated mRNA decay factor SMG9
      (term hierarchy)
    • InterPro Domains
      IPR039177 Nonsense-mediated mRNA decay factor SMG9
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    • GlyGen
      Q9DB90 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 56
      cDNA 56

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2141954, MGI:2142378
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 17
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:350444 Martinez-Mayer J, et al., Knockout mice with pituitary malformations help identify human cases of hypopituitarism. Genome Med. 2024 May 31;16(1):75
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory