C1qtnf1 MGI Mouse Gene Detail - MGI:1919254 - C1q and tumor necrosis factor related protein 1

Symbol

C1qtnf1
Name

C1q and tumor necrosis factor related protein 1
Synonyms

1600017K21Rik, CTRP1

Feature Type

protein coding gene
IDs

MGI:1919254
NCBI Gene: 56745
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr11:118319029-118340789 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 83.17 cM, cytoband E2
Mapping Data

2 experiments

SNPs within 2kb

727 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919254	protein coding gene	Chr11:118319029-118342608 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019468	protein coding gene	Chr11:122751881-122773380 (+)
A/J	MGP_AJ_G0019436	protein coding gene	Chr11:117315098-117337043 (+)
AKR/J	MGP_AKRJ_G0019406	protein coding gene	Chr11:120870044-120893416 (+)
BALB/cJ	MGP_BALBcJ_G0019411	protein coding gene	Chr11:117676527-117698777 (+)
C3H/HeJ	MGP_C3HHeJ_G0019217	protein coding gene	Chr11:121180224-121202836 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019860	protein coding gene	Chr11:126515067-126536883 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017485	protein coding gene	Chr11:114314495-114335692 (+)
CAST/EiJ	MGP_CASTEiJ_G0018771	protein coding gene	Chr11:122605201-122626447 (+)
CBA/J	MGP_CBAJ_G0019188	protein coding gene	Chr11:131428154-131449642 (+)
DBA/2J	MGP_DBA2J_G0019300	protein coding gene	Chr11:116696205-116718005 (+)
FVB/NJ	MGP_FVBNJ_G0019292	protein coding gene	Chr11:116342719-116364712 (+)
LP/J	MGP_LPJ_G0019370	protein coding gene	Chr11:123075388-123096804 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019325	protein coding gene	Chr11:130419659-130444477 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019899	protein coding gene	Chr11:121537485-121559020 (+)
PWK/PhJ	MGP_PWKPhJ_G0018537	protein coding gene	Chr11:118081742-118105287 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018329	protein coding gene	Chr11:121258296-121279475 (+)
WSB/EiJ	MGP_WSBEiJ_G0018823	protein coding gene	Chr11:121488273-121514017 (+)

Human Ortholog

C1QTNF1, C1q and TNF related 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

C1QTNF1, C1q and TNF related 1
Synonyms

CTRP1, GIP, ZSIG37
Links

HGNC:14324

NCBI Gene ID: 114897

neXtProt AC: NX_Q9BXJ1

UniProt: Q9BXJ1
Chr Location

17q25.3; chr17:79022814-79049788 (+) GRCh38

MGI Vertebrate Homology

C1qtnf1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: C1QTNF1
Gene Tree

C1qtnf1

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Phenotype Summary

34 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

2
Gene trapped

1
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit altered glucose and lipid homeostasis.

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All GO Annotations

22
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

761
Tissues

11
cDNA Data

74
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN c1qtnf1

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All Sequences

58
RefSeq

12
UniProt

5
CCDS

CCDS25703.1

Ensembl

ENSMUSG00000017446 (Evidence)
NCBI Gene

56745

			Length	Strain/Species	Flank
genomic	ENSMUSG00000017446	Ensembl Gene Model \| MGI Sequence Detail	21761	C57BL/6J	± kb
transcript	ENSMUST00000017590	Ensembl \| MGI Sequence Detail	2532	Not Applicable
polypeptide	ENSMUSP00000017590	Ensembl \| MGI Sequence Detail	281	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000004883 complement C1q tumor necrosis factor-related protein 1

(term hierarchy)
InterPro Domains

IPR001073 C1q domain

IPR050822 Cerebellin Synaptic Organizer

IPR008160 Collagen triple helix repeat

IPR008983 Tumour necrosis factor-like domain superfamily
GlyGen

Q9QXP7 1 site, 1 N-linked glycan (1 site)

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All nucleic 75

cDNA 74

Primer pair 1

Microarray probesets 5

Summaries

All 42

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for C1qtnf1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr106140	Chr11:118318941-118318967 (+)	-75 bp
Tssr106141	Chr11:118318976-118319017 (+)	-32 bp
Tssr106142	Chr11:118319034-118319057 (+)	17 bp
Tssr106143	Chr11:118319071-118319082 (+)	48 bp
Tssr106144	Chr11:118319099-118319110 (+)	76 bp
Tssr106145	Chr11:118319227-118319277 (+)	223 bp
Tssr106146	Chr11:118319284-118319294 (+)	260 bp
Tssr106147	Chr11:118319319-118319335 (+)	298 bp
Tssr106148	Chr11:118319343-118319374 (+)	330 bp
Tssr106149	Chr11:118324652-118324689 (+)	5,642 bp
Tssr106150	Chr11:118334341-118334363 (+)	15,323 bp
Tssr106151	Chr11:118340664-118340673 (+)	21,640 bp
Tssr106152	Chr11:118340699-118340712 (+)	21,677 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24