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Fndc3b Gene Detail
Summary
  • Symbol
    Fndc3b
  • Name
    fibronectin type III domain containing 3B
  • Synonyms
    1600019O04Rik, fad104
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919257
    NCBI Gene: 72007
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:27470311-27765456 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 10.91 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    8427 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919257
 protein coding gene Chr3:27470284-27765469 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027112
 protein coding gene Chr3:24735037-25053749 (-)
A/J MGP_AJ_G0027072
 protein coding gene Chr3:24547879-24845806 (-)
AKR/J MGP_AKRJ_G0027041
 protein coding gene Chr3:24864848-25176372 (-)
BALB/cJ MGP_BALBcJ_G0027084
 protein coding gene Chr3:24226810-24532280 (-)
C3H/HeJ MGP_C3HHeJ_G0026825
 protein coding gene Chr3:24902526-25211754 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027529
 protein coding gene Chr3:26110686-26430809 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024891
 protein coding gene Chr3:22558368-22852458 (-)
CAST/EiJ MGP_CASTEiJ_G0026280
 protein coding gene Chr3:24737735-25056022 (-)
CBA/J MGP_CBAJ_G0026803
 protein coding gene Chr3:26788692-27134616 (-)
DBA/2J MGP_DBA2J_G0026937
 protein coding gene Chr3:24095938-24394516 (-)
FVB/NJ MGP_FVBNJ_G0026905
 protein coding gene Chr3:23569660-23867479 (-)
LP/J MGP_LPJ_G0027049
 protein coding gene Chr3:25413482-25725031 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026926
 protein coding gene Chr3:29369938-29694613 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027589
 protein coding gene Chr3:24578667-24897565 (-)
PWK/PhJ MGP_PWKPhJ_G0026013
 protein coding gene Chr3:23554474-23861896 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025823
 protein coding gene Chr3:24110792-24428698 (-)
WSB/EiJ MGP_WSBEiJ_G0026353
 protein coding gene Chr3:24626418-24947937 (-)



Homology
more
  • Human Ortholog
    FNDC3B, fibronectin type III domain containing 3B
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FNDC3B, fibronectin type III domain containing 3B
  • Synonyms
    FAD104, PRO4979, YVTM2421
  • Links
    NCBI Gene ID: 64778
    neXtProt AC: NX_Q53EP0
    UniProt: Q53EP0

  • Chr Location
    3q26.31; chr3:172039578-172401669 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 3 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele die shortly after birth despite normal energy homeostasis. Mouse embryonic fibroblasts homozygous for a knock-out allele exhibit impaired adipogenesis and enhanced osteogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    802
  • Tissues
    37
  • cDNA Data
    14
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039286 Ensembl Gene Model | MGI Sequence Detail 295146 C57BL/6J ±  kb
    transcript ENSMUST00000195008 Ensembl | MGI Sequence Detail 6886 Not Applicable  
    polypeptide ENSMUSP00000141620 Ensembl | MGI Sequence Detail 1207 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000007588 fibronectin type III domain-containing protein 3B
      (term hierarchy)
    • InterPro Domains
      IPR050617 E3 ubiquitin-protein ligases and FN3/SPRY domain-containing proteins
      IPR003961 Fibronectin type III
      IPR036116 Fibronectin type III superfamily
      IPR013783 Immunoglobulin-like fold
    • GlyGen
      Q6NWW9 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 14

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2140001
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 5
      Phenotypes 21
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory