Cyb5r1 MGI Mouse Gene Detail - MGI:1919267

Symbol

Cyb5r1
Name

cytochrome b5 reductase 1
Synonyms

1500005G05Rik, B5R.1, Nqo3a2

Feature Type

protein coding gene
IDs

MGI:1919267
NCBI Gene: 72017
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr1:134333519-134339476 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 58.21 cM
Mapping Data

2 experiments

SNPs within 2kb

201 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919267	protein coding gene	Chr1:134333297-134339478 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016506	protein coding gene	Chr1:138064057-138070199 (+)
A/J	MGP_AJ_G0016489	protein coding gene	Chr1:132863685-132869824 (+)
AKR/J	MGP_AKRJ_G0016454	protein coding gene	Chr1:136824920-136836569 (+)
BALB/cJ	MGP_BALBcJ_G0016449	protein coding gene	Chr1:133198862-133205005 (+)
C3H/HeJ	MGP_C3HHeJ_G0016275	protein coding gene	Chr1:136928947-136935074 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016910	protein coding gene	Chr1:143097833-143104014 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014621	protein coding gene	Chr1:126001201-126007360 (+)
CAST/EiJ	MGP_CASTEiJ_G0015855	protein coding gene	Chr1:135983728-135989974 (+)
CBA/J	MGP_CBAJ_G0016248	protein coding gene	Chr1:148054863-148060999 (+)
DBA/2J	MGP_DBA2J_G0016354	protein coding gene	Chr1:131879404-131885500 (+)
FVB/NJ	MGP_FVBNJ_G0016353	protein coding gene	Chr1:130504518-130510614 (+)
LP/J	MGP_LPJ_G0016425	protein coding gene	Chr1:139342587-139348731 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016378	protein coding gene	Chr1:153744541-153750633 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016946	protein coding gene	Chr1:136561785-136567923 (+)
PWK/PhJ	MGP_PWKPhJ_G0015641	protein coding gene	Chr1:130902715-130908922 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015428	protein coding gene	Chr1:135535989-135544305 (+)
WSB/EiJ	MGP_WSBEiJ_G0015918	protein coding gene	Chr1:136594280-136600434 (+)

Human Ortholog

CYB5R1, cytochrome b5 reductase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CYB5R1, cytochrome b5 reductase 1
Synonyms

B5R.1, B5R1, B5R2, humb5R2, NQO3A2
Links

HGNC:13397

NCBI Gene ID: 51706

neXtProt AC: NX_Q9UHQ9

UniProt: Q9UHQ9
Chr Location

1q32.1; chr1:202961873-202967275 (-) GRCh38

MGI Vertebrate Homology

Cyb5r1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CYB5R1
Gene Tree

Cyb5r1

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Phenotype Summary

1 phenotype from 2 alleles in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

2
Gene trapped

7
Radiation induced

1
Targeted

4
Genomic Mutations

3 involving Cyb5r1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

32 strains or lines available

Homozygous knockout mice die before birth.

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All GO Annotations

11
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

94
cDNA Data

9
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cyb5r1

ZFIN cyb5r1

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All Sequences

56
RefSeq

5
UniProt

4
CCDS

CCDS15308.1

Ensembl

ENSMUSG00000026456 (Evidence)
NCBI Gene

72017

			Length	Strain/Species	Flank
genomic	72017	NCBI Gene Model \| MGI Sequence Detail	5958	C57BL/6J	± kb
transcript	NR_149307	RefSeq \| MGI Sequence Detail	2422	C57BL/6
polypeptide	Q9DB73	UniProt \| EBI \| MGI Sequence Detail	305	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000006080 NADH-cytochrome b5 reductase 1

(term hierarchy)
EC

1.6.2.2
InterPro Domains

IPR017927 FAD-binding domain, ferredoxin reductase-type

IPR039261 Ferredoxin-NADP reductase (FNR), nucleotide-binding domain

IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase

IPR008333 Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain

IPR001834 NADH:cytochrome b5 reductase-like

IPR001433 Oxidoreductase FAD/NAD(P)-binding

IPR017938 Riboflavin synthase-like beta-barrel

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All nucleic 9

cDNA 9

Microarray probesets 4

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MGI:2138690

Summaries

All 44

Developmental Gene Expression 1

Gene Ontology 9

Phenotypes 14
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:344225 Faber JE, et al., Large differences in collateral blood vessel abundance among individuals arise from multiple genetic variants. J Cereb Blood Flow Metab. 2023 Nov;43(11):1983-2004

TSS for Cyb5r1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8875	Chr1:134333440-134333462 (+)	-68 bp
Tssr8876	Chr1:134333463-134333474 (+)	-50 bp
Tssr8877	Chr1:134333506-134333530 (+)	-1 bp
Tssr8878	Chr1:134333540-134333551 (+)	27 bp
Tssr217	Chr1:134333703-134333708 (+)	187 bp
Tssr8879	Chr1:134333722-134333743 (+)	214 bp
Tssr8880	Chr1:134333755-134333767 (+)	242 bp
Tssr218	Chr1:134333789-134333800 (+)	276 bp
Tssr8881	Chr1:134334053-134334064 (+)	540 bp
Tssr8882	Chr1:134334072-134334095 (+)	565 bp
Tssr8883	Chr1:134334112-134334123 (+)	599 bp
Tssr8884	Chr1:134335824-134335867 (+)	2,327 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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