About   Help   FAQ
Fundc1 Gene Detail
Summary
  • Symbol
    Fundc1
  • Name
    FUN14 domain containing 1
  • Synonyms
    1500005J14Rik, 1810033P05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919268
    NCBI Gene: 72018
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:17422803-17438564 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 12.80 cM, cytoband A2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    333 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919268
 protein coding gene ChrX:17386206-17438600 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035583
 protein coding gene ChrX:12430862-12445266 (-)
A/J MGP_AJ_G0035560
 protein coding gene ChrX:12532853-12550799 (-)
AKR/J MGP_AKRJ_G0035492
 protein coding gene ChrX:12907326-12925542 (-)
BALB/cJ MGP_BALBcJ_G0035553
 protein coding gene ChrX:12322740-12337283 (-)
C3H/HeJ MGP_C3HHeJ_G0035270
 protein coding gene ChrX:12540473-12554942 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036088
 protein coding gene ChrX:12735353-12753174 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032953
 protein coding gene ChrX:11034976-11050562 (-)
CAST/EiJ MGP_CASTEiJ_G0034562
 protein coding gene ChrX:12094174-12109462 (-)
CBA/J MGP_CBAJ_G0035239
 protein coding gene ChrX:13321385-13335814 (-)
DBA/2J MGP_DBA2J_G0035391
 protein coding gene ChrX:12330404-12347578 (-)
FVB/NJ MGP_FVBNJ_G0035338
 protein coding gene ChrX:12235795-12250410 (-)
LP/J MGP_LPJ_G0035473
 protein coding gene ChrX:12747211-12761575 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035382
 protein coding gene ChrX:13471520-13485919 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036095
 protein coding gene ChrX:12343312-12357641 (-)
PWK/PhJ MGP_PWKPhJ_G0034263
 protein coding gene ChrX:11659250-11674449 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034102
 protein coding gene ChrX:12385049-12401970 (-)
WSB/EiJ MGP_WSBEiJ_G0034697
 protein coding gene ChrX:12309295-12327479 (-)



Homology
more
  • Human Ortholog
    FUNDC1, FUN14 domain containing 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FUNDC1, FUN14 domain containing 1
  • Links
    NCBI Gene ID: 139341
    neXtProt AC: NX_Q8IVP5
    UniProt: Q8IVP5

  • Chr Location
    Xp11.3; chrX:44523639-44542859 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
No abnormal phenotype was observed in a high-throughput screen, nor in a pathology assessment.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    1
  • cDNA Data
    70
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025040 Ensembl Gene Model | MGI Sequence Detail 15762 C57BL/6J ±  kb
    transcript ENSMUST00000026016 Ensembl | MGI Sequence Detail 1983 Not Applicable  
    polypeptide ENSMUSP00000026016 Ensembl | MGI Sequence Detail 155 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 70
      cDNA 70

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1916434
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 2
      Gene Ontology 8
      Phenotypes 22
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:348846 Guo X, et al., FUDNC1-dependent mitophagy ameliorate motor neuron death in an amyotrophic lateral sclerosis mouse model. Neurobiol Dis. 2024 May 15;197:106534
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory