Tnfrsf13c MGI Mouse Gene Detail - MGI:1919299 - tumor necrosis factor receptor superfamily, member 13c

Symbol

Tnfrsf13c
Name

tumor necrosis factor receptor superfamily, member 13c
Synonyms

2010006P15Rik, Baffr, BAFF-R, Bcmd-1, Bcmd1, Lvis22

Feature Type

protein coding gene
IDs

MGI:1919299
NCBI Gene: 72049
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr15:82105944-82108570 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 38.56 cM
Mapping Data

6 experiments

SNPs within 2kb

154 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919299	protein coding gene	Chr15:82105943-82108581 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022137	protein coding gene	Chr15:82719725-82721990 (-)
A/J	MGP_AJ_G0022097	protein coding gene	Chr15:79792298-79794778 (-)
AKR/J	MGP_AKRJ_G0022073	protein coding gene	Chr15:82002038-82004629 (-)
BALB/cJ	MGP_BALBcJ_G0022103	protein coding gene	Chr15:79839206-79842138 (-)
C3H/HeJ	MGP_C3HHeJ_G0021874	protein coding gene	Chr15:82018221-82021578 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022546	protein coding gene	Chr15:85958953-85963072 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020075	protein coding gene	Chr15:76229647-76232194 (-)
CAST/EiJ	MGP_CASTEiJ_G0021394	protein coding gene	Chr15:82816109-82818408 (-)
CBA/J	MGP_CBAJ_G0021839	protein coding gene	Chr15:88645256-88651460 (-)
DBA/2J	MGP_DBA2J_G0021967	protein coding gene	Chr15:79262314-79265374 (-)
FVB/NJ	MGP_FVBNJ_G0021944	protein coding gene	Chr15:78323114-78326094 (-)
LP/J	MGP_LPJ_G0022036	protein coding gene	Chr15:82865015-82869817 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021965	protein coding gene	Chr15:93552859-93556579 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022560	protein coding gene	Chr15:82113562-82116936 (-)
PWK/PhJ	MGP_PWKPhJ_G0021136	protein coding gene	Chr15:79316703-79319751 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020975	protein coding gene	Chr15:81895271-81898106 (-)
WSB/EiJ	MGP_WSBEiJ_G0021445	protein coding gene	Chr15:82527456-82532488 (-)

Human Ortholog

TNFRSF13C, TNF receptor superfamily member 13C

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TNFRSF13C, TNF receptor superfamily member 13C
Synonyms

BAFF-R, BAFFR, BROMIX, CD268, CVID4, prolixin
Links

HGNC:17755

NCBI Gene ID: 115650

neXtProt AC: NX_Q96RJ3

UniProt: Q96RJ3
Chr Location

22q13.2; chr22:41922032-41926806 (-) GRCh38

MGI Vertebrate Homology

Tnfrsf13c stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: TNFRSF13C
Gene Tree

Tnfrsf13c

Diseases

1 with human TNFRSF13C associations

				Human Disease	Mouse Models
				common variable immunodeficiency 4 IDs common variable immunodeficiency 4 DOID:0081147 OMIM:613494

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

26 phenotypes from 6 alleles in 7 genetic backgrounds
12 phenotypes from multigenic genotypes
72 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (ENU)

2
Chemically induced (other)

1
Endonuclease-mediated

5
Radiation induced

2
Spontaneous

1
Targeted

5
Genomic Mutations

3 involving Tnfrsf13c
Incidental Mutations

CvDC
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous inactivation of this gene results in defective splenic B-cell maturation, reduced marginal zone B-cell numbers, and impaired T-cell-dependent antibody formation.

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All GO Annotations

23
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

744
Tissues

27
cDNA Data

19
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

48
RefSeq

4
UniProt

6
CCDS

CCDS27684.1, CCDS88811.1

Ensembl

ENSMUSG00000068105 (Evidence)
NCBI Gene

72049

			Length	Strain/Species	Flank
genomic	ENSMUSG00000068105	Ensembl Gene Model \| MGI Sequence Detail	2627	C57BL/6J	± kb
transcript	ENSMUST00000109535	Ensembl \| MGI Sequence Detail	1983	Not Applicable
polypeptide	ENSMUSP00000105161	Ensembl \| MGI Sequence Detail	200	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000001957 tumor necrosis factor receptor superfamily member 13C

(term hierarchy)
InterPro Domains

IPR043521 Tumor necrosis factor receptor 13C/17

IPR022338 Tumour necrosis factor receptor 13C

IPR015336 Tumour necrosis factor receptor 13C, TALL-1 binding domain
GlyGen

Q9D8D0 1 site

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All nucleic 22

cDNA 19

Primer pair 3

Microarray probesets 2

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MGD-MRK-23965, MGI:103101

Summaries

All 119

Developmental Gene Expression 4

Diseases 1

Gene Ontology 6

Phenotypes 72
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:348944 Mockel T, et al., Transcriptome Analysis of BAFF/BAFF-R System in Murine Nephrotoxic Serum Nephritis. Int J Mol Sci. 2024 May 16;25(10)

TSS for Tnfrsf13c:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr135537	Chr15:82108565-82108580 (-)	-3 bp
Tssr135536	Chr15:82108531-82108562 (-)	23 bp
Tssr135535	Chr15:82107189-82107193 (-)	1,379 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24