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Cnot2 Gene Detail
Summary
  • Symbol
    Cnot2
  • Name
    CCR4-NOT transcription complex, subunit 2
  • Synonyms
    2600016M12Rik, 2810470K03Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919318
    NCBI Gene: 72068
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:116321066-116417416 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 64.76 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2042 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919318
 protein coding gene Chr10:116321065-116418891 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017746
 protein coding gene Chr10:119265100-119365436 (-)
A/J MGP_AJ_G0017722
 protein coding gene Chr10:114677126-114774223 (-)
AKR/J MGP_AKRJ_G0017684
 protein coding gene Chr10:117998440-118093761 (-)
BALB/cJ MGP_BALBcJ_G0017685
 protein coding gene Chr10:115079022-115174482 (-)
C3H/HeJ MGP_C3HHeJ_G0017510
 protein coding gene Chr10:118232724-118331343 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018142
 protein coding gene Chr10:123408508-123510502 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015822
 protein coding gene Chr10:109278895-109372641 (-)
CAST/EiJ MGP_CASTEiJ_G0017072
 protein coding gene Chr10:118512311-118618200 (-)
CBA/J MGP_CBAJ_G0017479
 protein coding gene Chr10:128239166-128345220 (-)
DBA/2J MGP_DBA2J_G0017584
 protein coding gene Chr10:113817380-113912968 (-)
FVB/NJ MGP_FVBNJ_G0017579
 protein coding gene Chr10:112772883-112868280 (-)
LP/J MGP_LPJ_G0017659
 protein coding gene Chr10:119848470-119947790 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017608
 protein coding gene Chr10:131137649-131241513 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018180
 protein coding gene Chr10:118068568-118168174 (-)
PWK/PhJ MGP_PWKPhJ_G0016854
 protein coding gene Chr10:113904297-114007053 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016644
 protein coding gene Chr10:116879215-116977021 (-)
WSB/EiJ MGP_WSBEiJ_G0017132
 protein coding gene Chr10:118244963-118345680 (-)



Homology
more
  • Human Ortholog
    CNOT2, CCR4-NOT transcription complex subunit 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CNOT2, CCR4-NOT transcription complex subunit 2
  • Synonyms
    CDC36, HSPC131, IDNADFS, NOT2, NOT2H
  • Links
    NCBI Gene ID: 4848
    neXtProt AC: NX_Q9NZN8
    UniProt: Q9NZN8

  • Chr Location
    12q15; chr12:70243002-70354993 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    789
  • Tissues
    71
  • cDNA Data
    25
  • Literature Summary
    9
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020166 Ensembl Gene Model | MGI Sequence Detail 96351 C57BL/6J ±  kb
transcript ENSMUST00000105267 Ensembl | MGI Sequence Detail 2800 Not Applicable  
polypeptide ENSMUSP00000100902 Ensembl | MGI Sequence Detail 540 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    10 Sequences
  • Protein Ontology
    PR:000005650 CCR4-NOT transcription complex subunit 2
    (term hierarchy)
  • InterPro Domains
    IPR038635 CCR4-NOT complex subunit 2/3/5, C-terminal domain superfamily
    IPR040168 Not2/Not3/Not5
    IPR007282 NOT2/NOT3/NOT5, C-terminal
  • GlyGen
    Q8C5L3 10 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (9 sites)
Molecular
Reagents
less
  • All nucleic 28
    Genomic 2
    cDNA 25
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:1925587, MGI:2143488, MGI:2143511, MGI:2143869, MGI:2143929
References
more
  • Summaries
    All 54
    Developmental Gene Expression 9
    Gene Ontology 7
    Phenotypes 17
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:311867 Zhang X, et al., Splicing factor Srsf5 deletion disrupts alternative splicing and causes noncompaction of ventricular myocardium. iScience. 2021 Oct 22;24(10):103097
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory