Gcnt3 MGI Mouse Gene Detail - MGI:1919327 - glucosaminyl (N-acetyl) transferase 3, mucin type

Symbol

Gcnt3
Name

glucosaminyl (N-acetyl) transferase 3, mucin type
Synonyms

2010013H22Rik, 2210021I22Rik, 2210401J11Rik

Feature Type

protein coding gene
IDs

MGI:1919327
NCBI Gene: 72077
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr9:69938778-69945370 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 39.20 cM, cytoband D
Mapping Data

2 experiments

SNPs within 2kb

291 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919327	protein coding gene	Chr9:69938777-69947172 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0034996	protein coding gene	Chr9:70066460-70073045 (-)
A/J	MGP_AJ_G0034977	protein coding gene	Chr9:67650255-67656829 (-)
AKR/J	MGP_AKRJ_G0034906	protein coding gene	Chr9:69254756-69261346 (-)
BALB/cJ	MGP_BALBcJ_G0034969	protein coding gene	Chr9:67372397-67378979 (-)
C3H/HeJ	MGP_C3HHeJ_G0034678	protein coding gene	Chr9:69758389-69765553 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0035488	protein coding gene	Chr9:71938785-71945371 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032399	protein coding gene	Chr9:67207403-67214177 (-)
CAST/EiJ	MGP_CASTEiJ_G0034000	protein coding gene	Chr9:70030680-70037206 (-)
CBA/J	MGP_CBAJ_G0034651	protein coding gene	Chr9:74447476-74454053 (-)
DBA/2J	MGP_DBA2J_G0034810	protein coding gene	Chr9:67395146-67401530 (-)
FVB/NJ	MGP_FVBNJ_G0034752	protein coding gene	Chr9:66713782-66720360 (-)
LP/J	MGP_LPJ_G0034891	protein coding gene	Chr9:70313910-70320329 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034793	protein coding gene	Chr9:75536196-75544655 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035510	protein coding gene	Chr9:69393116-69400391 (-)
PWK/PhJ	MGP_PWKPhJ_G0033704	protein coding gene	Chr9:67626434-67633335 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0033537	protein coding gene	Chr9:69700562-69707099 (-)
WSB/EiJ	MGP_WSBEiJ_G0034112	protein coding gene	Chr9:69283451-69290043 (-)

Human Ortholog

GCNT3, glucosaminyl (N-acetyl) transferase 3, mucin type

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GCNT3, glucosaminyl (N-acetyl) transferase 3, mucin type
Synonyms

C24GNT, C2/4GnT, C2GNT2, C2GNTM, GNTM
Links

HGNC:4205

NCBI Gene ID: 9245

neXtProt AC: NX_O95395

UniProt: O95395
Chr Location

15q22.2; chr15:59549039-59640239 (+) GRCh38

MGI Vertebrate Homology

Gcnt3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GCNT3
Gene Tree

Gcnt3

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Phenotype Summary

8 phenotypes from 2 alleles in 1 genetic background
2 phenotypes from multigenic genotypes
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

1
Targeted

4
Genomic Mutations

1 involving Gcnt3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygote null mice have decreases in core 2 O-glycan structures on cell surfaces, decreased immunoglobulin levels, and disrupted mucosal barrier in the intestines.

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All GO Annotations

15
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

94
cDNA Data

10
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

45
RefSeq

14
UniProt

1
CCDS

CCDS40678.1

Ensembl

ENSMUSG00000032226 (Evidence)
NCBI Gene

72077

			Length	Strain/Species	Flank
genomic	ENSMUSG00000032226	Ensembl Gene Model \| MGI Sequence Detail	6593	C57BL/6J	± kb
transcript	ENSMUST00000034751	Ensembl \| MGI Sequence Detail	4301	Not Applicable
polypeptide	ENSMUSP00000034751	Ensembl \| MGI Sequence Detail	437	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000007905 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3

(term hierarchy)
EC

2.4.1.102, 2.4.1.148, 2.4.1.150
InterPro Domains

IPR003406 Glycosyl transferase, family 14
GlyGen

Q5JCT0 1 site

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All nucleic 10

cDNA 10

Microarray probesets 5

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MGI:1917325, MGI:1917367

Summaries

All 41

Developmental Gene Expression 2

Gene Ontology 7

Phenotypes 13
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:294106 Soulez M, et al., Reevaluation of the Role of Extracellular Signal-Regulated Kinase 3 in Perinatal Survival and Postnatal Growth Using New Genetically Engineered Mouse Models. Mol Cell Biol. 2019 Mar 15;39(6)

TSS for Gcnt3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr90394	Chr9:69945378-69945391 (-)	-15 bp
Tssr90393	Chr9:69945357-69945375 (-)	4 bp
Tssr90392	Chr9:69945336-69945339 (-)	32 bp
Tssr90391	Chr9:69945325-69945334 (-)	40 bp
Tssr90390	Chr9:69945275-69945300 (-)	82 bp
Tssr90389	Chr9:69945233-69945242 (-)	132 bp
Tssr90388	Chr9:69944100-69944123 (-)	1,258 bp
Tssr90387	Chr9:69944092-69944099 (-)	1,274 bp
Tssr90386	Chr9:69944077-69944084 (-)	1,289 bp
Tssr90385	Chr9:69944010-69944021 (-)	1,354 bp
Tssr90384	Chr9:69943987-69943993 (-)	1,380 bp
Tssr90383	Chr9:69943963-69943986 (-)	1,395 bp
Tssr90382	Chr9:69942838-69942856 (-)	2,523 bp
Tssr90381	Chr9:69939916-69939919 (-)	5,452 bp
Tssr90380	Chr9:69939726-69939730 (-)	5,642 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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