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Sapcd2 Gene Detail
Summary
  • Symbol
    Sapcd2
  • Name
    suppressor APC domain containing 2
  • Synonyms
    2010317E24Rik, 6030458L21Rik, ang
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919330
    NCBI Gene: 72080
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:25262333-25268225 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 17.20 cM, cytoband A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    254 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919330
 protein coding gene Chr2:25261974-25268225 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025442
 protein coding gene Chr2:23255138-23261034 (+)
A/J MGP_AJ_G0025419
 protein coding gene Chr2:22355962-22361864 (+)
AKR/J MGP_AKRJ_G0025389
 protein coding gene Chr2:23102986-23108888 (+)
BALB/cJ MGP_BALBcJ_G0025415
 protein coding gene Chr2:22468411-22474303 (+)
C3H/HeJ MGP_C3HHeJ_G0025176
 protein coding gene Chr2:23037208-23043100 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025859
 protein coding gene Chr2:24001473-24007365 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023270
 protein coding gene Chr2:21265969-21271843 (+)
CAST/EiJ MGP_CASTEiJ_G0024639
 protein coding gene Chr2:22913853-22919711 (+)
CBA/J MGP_CBAJ_G0025154
 protein coding gene Chr2:24827348-24833240 (+)
DBA/2J MGP_DBA2J_G0025287
 protein coding gene Chr2:22194829-22200731 (+)
FVB/NJ MGP_FVBNJ_G0025249
 protein coding gene Chr2:21937891-21943783 (+)
LP/J MGP_LPJ_G0025373
 protein coding gene Chr2:23196650-23202544 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025280
 protein coding gene Chr2:25022915-25028817 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025918
 protein coding gene Chr2:23053106-23059000 (+)
PWK/PhJ MGP_PWKPhJ_G0024387
 protein coding gene Chr2:22010663-22016538 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024187
 protein coding gene Chr2:23199800-23205671 (+)
WSB/EiJ MGP_WSBEiJ_G0024708
 protein coding gene Chr2:23124672-23130574 (+)



Homology
more
  • Human Ortholog
    SAPCD2, suppressor APC domain containing 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SAPCD2, suppressor APC domain containing 2
  • Synonyms
    C9orf140, p42.3
  • Links
    NCBI Gene ID: 89958
    neXtProt AC: NX_Q86UD0
    UniProt: Q86UD0

  • Chr Location
    9q34.3; chr9:137062127-137070557 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Mice homozygous for disruptions in this gene display an apparently normal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    5
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    728
  • Tissues
    15
  • cDNA Data
    33
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026955 Ensembl Gene Model | MGI Sequence Detail 5893 C57BL/6J ±  kb
transcript ENSMUST00000100323 Ensembl | MGI Sequence Detail 1761 Not Applicable  
polypeptide ENSMUSP00000097898 Ensembl | MGI Sequence Detail 446 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000031335 suppressor APC domain-containing protein 2
    (term hierarchy)
  • InterPro Domains
    IPR026828 Suppressor APC domain-containing protein 1/2
  • GlyGen
    Q9D818 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 36
    cDNA 33
    Primer pair 2
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:1925607, MGI:2139141
References
more
  • Summaries
    All 32
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:239972 Chiu CW, et al., SAPCD2 Controls Spindle Orientation and Asymmetric Divisions by Negatively Regulating the Galphai-LGN-NuMA Ternary Complex. Dev Cell. 2016 Jan 11;36(1):50-62
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory