Snx12 MGI Mouse Gene Detail - MGI:1919331

Symbol

Snx12
Name

sorting nexin 12
Synonyms

2610001F05Rik

Feature Type

protein coding gene
IDs

MGI:1919331
NCBI Gene: 55988
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

ChrX:100141392-100266169 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 43.72 cM, cytoband C2
Mapping Data

3 experiments

SNPs within 2kb

1917 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919331	protein coding gene	ChrX:100132973-100266185 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0035952	protein coding gene	ChrX:97582145-97715914 (-)
A/J	MGP_AJ_G0035937	protein coding gene	ChrX:97596128-97726708 (-)
AKR/J	MGP_AKRJ_G0035853	protein coding gene	ChrX:100389998-100521532 (-)
BALB/cJ	MGP_BALBcJ_G0035920	protein coding gene	ChrX:96343291-96466282 (-)
C3H/HeJ	MGP_C3HHeJ_G0035629	protein coding gene	ChrX:97991013-98128024 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0036449	protein coding gene	ChrX:100492446-100627471 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033279	protein coding gene	ChrX:95352720-95481286 (-)
CAST/EiJ	MGP_CASTEiJ_G0034916	protein coding gene	ChrX:82298857-82429944 (-)
CBA/J	MGP_CBAJ_G0035604	protein coding gene	ChrX:103604352-103737794 (-)
DBA/2J	MGP_DBA2J_G0035758	protein coding gene	ChrX:96808339-96936542 (-)
FVB/NJ	MGP_FVBNJ_G0035696	protein coding gene	ChrX:96198635-96322685 (-)
LP/J	MGP_LPJ_G0035848	protein coding gene	ChrX:98550222-98682764 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035731	protein coding gene	ChrX:108158526-108292330 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036476	protein coding gene	ChrX:97285750-97412511 (-)
PWK/PhJ	MGP_PWKPhJ_G0034615	protein coding gene	ChrX:79910465-80040428 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0034443	protein coding gene	ChrX:83199004-83328095 (-)
WSB/EiJ	MGP_WSBEiJ_G0035055	protein coding gene	ChrX:95991918-96117968 (-)

Human Ortholog

SNX12, sorting nexin 12

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SNX12, sorting nexin 12
Links

HGNC:14976

NCBI Gene ID: 29934

neXtProt AC: NX_Q9UMY4

UniProt: Q9UMY4
Chr Location

Xq13.1; chrX:71056332-71073426 (-) GRCh38

MGI Vertebrate Homology

Snx12 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SNX12
Gene Tree

Snx12

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
5 images
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

24
Endonuclease-mediated

1
Gene trapped

21
Targeted

2
Incidental Mutations

CvDC
Find Mice (IMSR)

6 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Male chimeras hemizygous for a gene trapped allele appear normal at E9.5.

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All GO Annotations

17
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

777
Tissues

32
cDNA Data

83
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase snx12

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All Sequences

69
RefSeq

12
UniProt

5
CCDS

CCDS41076.1, CCDS53151.1, CCDS53152.1

Ensembl

ENSMUSG00000046032 (Evidence)
NCBI Gene

55988

			Length	Strain/Species	Flank
genomic	ENSMUSG00000046032	Ensembl Gene Model \| MGI Sequence Detail	124778	C57BL/6J	± kb
transcript	ENSMUST00000156473	Ensembl \| MGI Sequence Detail	1114	Not Applicable
polypeptide	ENSMUSP00000119102	Ensembl \| MGI Sequence Detail	170	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000015361 sorting nexin-12

(term hierarchy)
InterPro Domains

IPR001683 Phox homology

IPR036871 PX domain superfamily

IPR051074 Sorting Nexin

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All nucleic 84

cDNA 83

Primer pair 1

Microarray probesets 6

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MGI:2147988

Summaries

All 38

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Snx12:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr163862	ChrX:100266032-100266167 (-)	69 bp
Tssr163861	ChrX:100257092-100257136 (-)	9,055 bp
Tssr163860	ChrX:100257050-100257066 (-)	9,111 bp
Tssr163859	ChrX:100256497-100256518 (-)	9,661 bp
Tssr163858	ChrX:100256470-100256490 (-)	9,689 bp
Tssr163857	ChrX:100256425-100256446 (-)	9,733 bp
Tssr163856	ChrX:100256414-100256420 (-)	9,752 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24