Tpx2 MGI Mouse Gene Detail - MGI:1919369 - TPX2, microtubule-associated

Symbol

Tpx2
Name

TPX2, microtubule-associated
Synonyms

2610005B21Rik, DIL2, p100, REPP86

Feature Type

protein coding gene
IDs

MGI:1919369
NCBI Gene: 72119
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr2:152689884-152737241 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 75.41 cM, cytoband H2
Mapping Data

2 experiments

SNPs within 2kb

1046 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919369	protein coding gene	Chr2:152689859-152737241 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026679	protein coding gene	Chr2:157435417-157493828 (+)
A/J	MGP_AJ_G0026645	protein coding gene	Chr2:151146869-151194434 (+)
AKR/J	MGP_AKRJ_G0026615	protein coding gene	Chr2:155564008-155614704 (+)
BALB/cJ	MGP_BALBcJ_G0026654	protein coding gene	Chr2:151456668-151504166 (+)
C3H/HeJ	MGP_C3HHeJ_G0026397	protein coding gene	Chr2:155935983-155985681 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027103	protein coding gene	Chr2:161997861-162054872 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024474	protein coding gene	Chr2:144736995-144786210 (+)
CAST/EiJ	MGP_CASTEiJ_G0025858	protein coding gene	Chr2:156190755-156241435 (+)
CBA/J	MGP_CBAJ_G0026375	protein coding gene	Chr2:167962511-168024156 (+)
DBA/2J	MGP_DBA2J_G0026511	protein coding gene	Chr2:150356803-150404783 (+)
FVB/NJ	MGP_FVBNJ_G0026477	protein coding gene	Chr2:148816568-148868403 (+)
LP/J	MGP_LPJ_G0026615	protein coding gene	Chr2:157586338-157642419 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026498	protein coding gene	Chr2:172040627-172091067 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027159	protein coding gene	Chr2:155453621-155506064 (+)
PWK/PhJ	MGP_PWKPhJ_G0025592	protein coding gene	Chr2:149880517-149928734 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025395	protein coding gene	Chr2:154294833-154340941 (+)
WSB/EiJ	MGP_WSBEiJ_G0025928	protein coding gene	Chr2:156361255-156412429 (+)

Human Ortholog

TPX2, TPX2 microtubule nucleation factor

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TPX2, TPX2 microtubule nucleation factor
Synonyms

C20orf1, C20orf2, DIL-2, DIL2, FLS353, GD:C20orf1, HCA519, HCTP4, p100, REPP86
Links

HGNC:1249

NCBI Gene ID: 22974

neXtProt AC: NX_Q9ULW0

UniProt: Q9ULW0
Chr Location

20q11.21; chr20:31739271-31801805 (+) GRCh38

MGI Vertebrate Homology

Tpx2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TPX2
Gene Tree

Tpx2

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Phenotype Summary

22 phenotypes from 4 alleles in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

100
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

95
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Tpx2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

110 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trap allele exhibit embryonic arrest at the morula stage, embryonic lethality and tetraploidy of cultured E1.5 embryos. Mice heterozygous for the gene trap allele exhibit aneuploidy and increased tumor incidence.

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All GO Annotations

41
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

721
Tissues

6
cDNA Data

16
Literature Summary

12

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tpx2

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All Sequences

67
RefSeq

16
UniProt

3
CCDS

CCDS16900.1

Ensembl

ENSMUSG00000027469 (Evidence)
NCBI Gene

72119

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027469	Ensembl Gene Model \| MGI Sequence Detail	47358	C57BL/6J	± kb
transcript	ENSMUST00000109816	Ensembl \| MGI Sequence Detail	3483	Not Applicable
polypeptide	ENSMUSP00000105441	Ensembl \| MGI Sequence Detail	745	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000016598 targeting protein for Xklp2

(term hierarchy)
InterPro Domains

IPR015128 Aurora-A binding

IPR009675 TPX2

IPR027330 TPX2 central domain

IPR027329 TPX2, C-terminal
GlyGen

A2APB8 1 site, 1 O-linked glycan (1 site)

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All nucleic 18

cDNA 16

Primer pair 1

Other 1

Microarray probesets 5

Summaries

All 58

Developmental Gene Expression 12

Gene Ontology 10

Phenotypes 14
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:354248 Vial Y, et al., Mcph1, mutated in primary microcephaly, is also crucial for erythropoiesis. EMBO Rep. 2024 May;25(5):2418-2440

TSS for Tpx2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr20840	Chr2:152689881-152689892 (+)	3 bp
Tssr20841	Chr2:152689913-152689996 (+)	71 bp
Tssr20842	Chr2:152709162-152709184 (+)	19,289 bp
Tssr20843	Chr2:152711372-152711381 (+)	21,493 bp
Tssr20844	Chr2:152711462-152711473 (+)	21,584 bp
Tssr20845	Chr2:152718465-152718502 (+)	28,600 bp
Tssr20846	Chr2:152718514-152718528 (+)	28,637 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24