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Pex13 Gene Detail
Summary
  • Symbol
    Pex13
  • Name
    peroxisomal biogenesis factor 13
  • Synonyms
    2610008O20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919379
    NCBI Gene: 72129
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:23597283-23615883 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 14.34 cM, cytoband A3.3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    363 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919379
 protein coding gene Chr11:23596479-23615959 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018090
 protein coding gene Chr11:21415953-21437285 (-)
A/J MGP_AJ_G0018063
 protein coding gene Chr11:20576532-20596003 (-)
AKR/J MGP_AKRJ_G0018027
 protein coding gene Chr11:21312238-21331710 (-)
BALB/cJ MGP_BALBcJ_G0018031
 protein coding gene Chr11:20716980-20736440 (-)
C3H/HeJ MGP_C3HHeJ_G0017845
 protein coding gene Chr11:21196056-21215500 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018483
 protein coding gene Chr11:22273920-22294919 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016141
 protein coding gene Chr11:19478578-19496383 (-)
CAST/EiJ MGP_CASTEiJ_G0017406
 protein coding gene Chr11:21224769-21241350 (-)
CBA/J MGP_CBAJ_G0017819
 protein coding gene Chr11:23260621-23282309 (-)
DBA/2J MGP_DBA2J_G0017929
 protein coding gene Chr11:20500460-20519866 (-)
FVB/NJ MGP_FVBNJ_G0017921
 protein coding gene Chr11:20281818-20301624 (-)
LP/J MGP_LPJ_G0018000
 protein coding gene Chr11:21505878-21526407 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017947
 protein coding gene Chr11:23794691-23817254 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018524
 protein coding gene Chr11:21426433-21445885 (-)
PWK/PhJ MGP_PWKPhJ_G0017187
 protein coding gene Chr11:20548870-20568734 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016984
 protein coding gene Chr11:21167818-21188745 (-)
WSB/EiJ MGP_WSBEiJ_G0017460
 protein coding gene Chr11:21056835-21076973 (-)



Homology
more
  • Human Ortholog
    PEX13, peroxisomal biogenesis factor 13
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PEX13, peroxisomal biogenesis factor 13
  • Synonyms
    NALD, PBD11A, PBD11B, ZWS
  • Links
    NCBI Gene ID: 5194
    neXtProt AC: NX_Q92968
    UniProt: Q92968

  • Chr Location
    2p15; chr2:61017225-61051990 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human PEX13 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    42 phenotypes from 2 alleles in 2 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted disruption of this gene results in intrauterine growth retardation, hypotonia, aphagia, abnormal lamination of the cerebral cortex associated with a neuronal migration defect, liver steatosis, delayed differentiation of renal glomeruli, impairedperoxisome metabolism, and neonatal death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    2
  • cDNA Data
    16
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 72129 NCBI Gene Model | MGI Sequence Detail 18601 C57BL/6J ±  kb
    transcript NM_023651 RefSeq | MGI Sequence Detail 3266 C57BL/6  
    polypeptide Q9D0K1 UniProt | EBI | MGI Sequence Detail 405 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 16

      Microarray probesets 6
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 3
      Gene Ontology 12
      Phenotypes 20
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:299445 Rishi G, et al., Hepatocyte-specific deletion of peroxisomal protein PEX13 results in disrupted iron homeostasis. Biochim Biophys Acta Mol Basis Dis. 2020 Oct 1;1866(10):165882
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory